This work is a micromagnetic simulation-based study on the GHz-frequency ferromagnetic resonances (FMR) for the detection of magnetic nanoparticles (MNPs) using spin current nano-oscillator (SCNO) operating in precession mode. Capture antibody-antigen-detection antibody-MNP complex on the SCNO surface generates magnetic fields that modify the FMR peaks and generate measurable resonance peak shifts. Moreover, our results strongly indicate the position-sensitive behavior of the SCNO biosensor and demonstrate ways to eradicate this effect to facilitate improved bio-sensing. Additionally, a study has been made on how MNPs with different sizes can alter the SCNO device performance. This simulation-based study on the SCNO device shows the feasibility of a frequency-based nano-biosensor with the sensitivity of detecting a single MNP, even in presence of background noise.

中文翻译：

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自旋电流纳米振荡器 (SCNO) 作为基于潜在频率的超灵敏磁性生物传感器：模拟研究

这项工作是基于 GHz 频率铁磁共振 (FMR) 的微磁模拟研究，用于使用在进动模式下运行的自旋电流纳米振荡器 (SCNO) 检测磁性纳米粒子 (MNP)。SCNO 表面上的捕获抗体-抗原-检测抗体-MNP 复合物会产生磁场，从而修改 FMR 峰并产生可测量的共振峰位移。此外，我们的结果强烈表明 SCNO 生物传感器的位置敏感行为，并展示了消除这种影响以促进改善生物传感的方法。此外，还对不同尺寸的 MNP 如何改变 SCNO 设备性能进行了研究。这项基于模拟的 SCNO 设备研究显示了基于频率的纳米生物传感器具有检测单个 MNP 的灵敏度的可行性，