Opioid signaling plays a central role in pain perception. As such, it remains the main target in the development of antinociceptive agents, despite serious side effects involved. In recent years, hopes for improved opioid painkillers are rising, together with our understanding of allosterism and biased signaling mechanisms. In this review, we focus on recently discovered allosteric modulators of opioid receptors, insights into phenomena underlying their action, as well as on how they extend our understanding of mechanisms of previously known compounds. A brief overlook of their synthesis is also presented.

中文翻译：

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减轻疼痛 - 阿片受体的变构调节概述：调节机制、变构位点、调节剂合成。

阿片类信号在疼痛感知中起着核心作用。因此，尽管涉及严重的副作用，但它仍然是开发镇痛剂的主要目标。近年来，随着我们对变构和偏向信号机制的理解，人们对改进的阿片类止痛药的希望越来越高。在这篇综述中，我们重点关注最近发现的阿片受体变构调节剂，深入了解其作用背后的现象，以及它们如何扩展我们对先前已知化合物机制的理解。还简要介绍了它们的合成。