Atherosclerosis is a multifactorial disease that develops and progresses in the arterial wall in response to a variety of stimuli. Among various other stimuli, hyperlipidemia is an extremely important factor that is correlated with the development of atherosclerosis. Lemon and citrus fruits contain various bioactive flavonoids, such as eriocitrin, that prevent obesity and related metabolic diseases. Therefore we concentrated on eriocitrin, a potent flavonoid with numerous therapeutic properties, particularly its beneficial lipid-lowering action in rats subjected to high fat diet. The anti-atherosclerotic efficacy of eriocitrin was assessed in rats administered a diet rich in fat. Wistar rats were divided into five groups consisting of six animals in all groups. Group I served the control, Group II was fed a high-fat diet (HFD), and the third and fourth groups were fed an HFD supplemented with varying doses of eriocitrin, and the last group was administered simvastatin for the last 30 days. Body weight, organ weight, lipid and lipoprotein parameters, cardiac and inflammatory markers, and histological examination were evaluated in animals induced with an HFD. Eriocitrin displayed a significant anti-atherosclerotic action by lowering the body weight, organ weight, reduction in lipid content, cardiac and inflammatory markers, myocardial changes confirmed by histopathology, malondialdehyde and increased antioxidant enzyme activities, nitric oxide, as well as 6-keto-PGF1α and high-density lipoprotein levels in rats fed an HFD. The findings of the experiment suggest that the anti-atherosclerotic action of eriocitrin was due to its modulatory activity in lipid metabolism. Considering the overall results of the study it can be validated that a use of flavonoid eriocitrin might be beneficial in altering HFD-induced alterations in atherosclerotic rats.

中文翻译：

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Eriocitrin在高脂饮食诱导的动脉粥样硬化模型大鼠中的抗动脉粥样硬化活性。

动脉粥样硬化是响应多种刺激在动脉壁中发展和发展的多因素疾病。在各种其他刺激中，高脂血症是与动脉粥样硬化发展相关的极其重要的因素。柠檬和柑桔类水果中含有多种生物活性类黄酮，如艾草黄碱，可预防肥胖症和相关的代谢性疾病。因此，我们集中研究了eriocitrin，一种有效的类黄酮，具有多种治疗特性，尤其是在高脂饮食大鼠中具有有益的降脂作用。在给予高脂饮食的大鼠中评估了草酸甘油酯的抗动脉粥样硬化功效。将Wistar大鼠分为五组，每组六只动物。第一组为对照组，第二组为高脂饮食（HFD），第三组和第四组分别接受补充了不同剂量的Eriocitrin的HFD喂养，最后一组在最后30天服用辛伐他汀。在用HFD诱导的动物中评估了体重，器官重量，脂质和脂蛋白参数，心脏和炎症标志物以及组织学检查。Eriocitrin通过降低体重，器官重量，减少脂质含量，心脏和炎性标志物，组织病理学证实的心肌变化，丙二醛和增加的抗氧化酶活性，一氧化氮以及6-酮-酮，显示出显着的抗动脉粥样硬化作用。喂HFD的大鼠中PGF1α和高密度脂蛋白水平。实验的结果表明，芥酸的抗动脉粥样硬化作用是由于其在脂质代谢中的调节活性。