Colon cancer (CC) is the most common type of gastrointestinal cancer and is the third leading cause of cancer patient's death worldwide. Long non-coding RNAs (lncRNAs) are important regulatory molecules involved in various cellular processes, and many of them are shown as significant prognosis biomarkers of malignant tumors. In the present study, we identified differentially expressed lncRNAs between CC and adjacent normal tissues based on two TCGA database (GEPIA and circlncRNAnet). Over 1500 differentially expressed lncRNAs between CC and adjacent normal tissues were obtained based on these two websites, and 72 lncRNAs (FC > = 2, Log2 (TPM+1) > 1, P < 0.05) were chosen for further analysis. Seventeen of them were CC specific-expressed lncRNAs. We then evaluated the expression of the 17 lncRNAs in diverse tumor stage. LncRNA double homeobox A pseudogene 8 (DUXAP8), RP11-54H7.4, and RP11-138J23.1 showed higher expression in later tumor stages. Built on survival analysis, we found that high expression of DUXAP8 and ELFN1 antisense RNA 1 (ELFN1-AS1) predicts poor prognosis in CC. In addition, high expression of the 17 lncRNAs set predicts poor prognosis in CC. This study provides a new way to evaluate the prognosis of CC.

中文翻译：

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潜在的致癌长非编码RNA的鉴定作为与结肠癌预后相关的生物标志物。

结肠癌（CC）是最常见的胃肠道癌症，是全世界癌症患者死亡的第三大主要原因。长的非编码RNA（lncRNA）是参与各种细胞过程的重要调控分子，其中许多被证明是恶性肿瘤的重要预后生物标志物。在本研究中，我们基于两个TCGA数据库（GEPIA和circlncRNAnetnet）在CC和相邻正常组织之间鉴定了差异表达的lncRNA。基于这两个网站，在CC和邻近正常组织之间获得了1500多个差异表达的lncRNA，并选择了72个lncRNA（FC> = 2，Log2（TPM + 1）> 1，P <0.05）进行进一步分析。其中十七个是CC特异性表达的lncRNA。然后，我们评估了17种lncRNA在不同肿瘤阶段的表达。LncRNA双同源盒A假基因8（DUXAP8），RP11-54H7.4和RP11-138J23.1在晚期肿瘤阶段显示较高的表达。基于生存分析，我们发现DUXAP8和ELFN1反义RNA 1（ELFN1-AS1）的高表达预示着CC的不良预后。此外，17种lncRNA的高表达预示着CC的不良预后。这项研究提供了评估CC预后的新方法。