Cancer immune-interception for prevention of recurrence in patients with high-risk familial cancer like Muir–Torre syndrome or Lynch syndrome using immune checkpoint blockade inhibitors is a promising approach. Albeit, as described in a case report by Pollak and colleagues in the April 2020 issue of Cancer Prevention Research, it has the potential to be used as immune-interceptive with alternative dosing regimens for cancers with microsatellite instability. The combination of additional cancer preventive and immunopreventive approaches, such as vaccines and minimal dose of immune checkpoint blockade inhibitors, is another unexplored modality for cancer interception in high-risk individuals.

中文翻译：

---

高危癌症患者的免疫拦截

使用免疫检查点阻断抑制剂预防高危家族性癌症（如 Muir-Torre 综合征或 Lynch 综合征）患者的癌症免疫拦截是一种很有前景的方法。尽管如 Pollak 及其同事在 2020 年 4 月出版的《癌症预防研究》中的病例报告中所描述的那样，它有可能被用作免疫拦截剂，并与微卫星不稳定性癌症的替代给药方案一起使用。其他癌症预防和免疫预防方法的组合，例如疫苗和最小剂量的免疫检查点阻断抑制剂，是另一种尚未探索的高危人群癌症拦截方式。