The overall success of nanocarriers in biomedical applications depends on their interaction with different proteins in blood. Immunoglobulins as a major protein class of the blood proteome may considerably influence the identity of the nanocarriers in blood. However, there is a lack of knowledge about the specific details of the interaction mechanism between different immunoglobulins and nanocarriers. Therefore, the authors have investigated the interaction of different immunoglobulin classes—namely, immunoglobulin G, A, and M—with different polystyrene model nanoparticles. The authors report that immunoglobulin interaction with nanoparticles strongly depends on the immunoglobulin class and surface charge of the nanoparticles. Furthermore, upon adsorption on the nanoparticles’ surfaces, aggregation processes and denaturation of immunoglobulins were observed. This highlights the importance of nanocarriers’ design in order to prevent unfavorable denaturation and adsorption processes of immunoglobulins on nanoparticle surfaces.

中文翻译：

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电荷不同的聚合物纳米颗粒表面上的免疫球蛋白。

纳米载体在生物医学应用中的总体成功取决于它们与血液中不同蛋白质的相互作用。免疫球蛋白是血液蛋白质组中的主要蛋白质类别，可能会大大影响血液中纳米载体的身份。但是，缺乏有关不同免疫球蛋白和纳米载体之间相互作用机制的具体细节的知识。因此，作者研究了不同免疫球蛋白类别（即，免疫球蛋白G，A和M）与不同聚苯乙烯模型纳米颗粒的相互作用。作者报告说，免疫球蛋白与纳米颗粒的相互作用在很大程度上取决于免疫球蛋白的种类和纳米颗粒的表面电荷。此外，一旦吸附在纳米颗粒的表面，观察到免疫球蛋白的聚集过程和变性。这突出了纳米载体设计的重要性，以防止免疫球蛋白在纳米粒子表面发生不利的变性和吸附过程。