Abstract Polymorphic variants in the PTEN (rs2735343), PI3K (rs2699887), AKT1 (rs2494750), AR (rs17302090), and AMACR (rs3195676) genes were evaluated as possible molecular markers of susceptibility, prognosis, and progression of prostate cancer (PCa), in a case-control study. Samples consisted of 277 patients with PCa and 277 controls from Londrina, PR, Brazil. SNPs were analyzed by real-time PCR. A family history of cancer, including PCa, as well as level of schooling were risk factors for PCa. The data were obtained via logistic regression, using odds ratios with a CI 95%. The genotypes of AKT1 and AKT1+AR demonstrated an association with protection for the disease. The combination of SNPs with the histopathological tumor data between allele variants of AMACR, AKT1+AR, and AKT1+AMACR indicated an association with protection against seminal vesicle invasion. The polymorphisms AKT1+AR and PI3K+AR were associated with protection against tumor bilaterality. The genotype combinations PTEN+AMACR and PTEN+AR were associated with the risk of extracapsular extension. Of the five genes studied, two were associated with protection for PCa, four were associated with protection for some prognostic variables, and only one was associated with risk. Thus, these SNPs are candidates for markers to discriminate men with better or worse prognosis for PCa.

中文翻译：

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前列腺癌患者PTEN、AKT1、PI3K、AR和AMACR基因多态性的相关性

摘要 PTEN (rs2735343)、PI3K (rs2699887)、AKT1 (rs2494750)、AR (rs17302090) 和 AMACR (rs3195676) 基因中的多态性变异被评估为前列腺癌易感性、预后和进展的可能分子标志物，在病例对照研究中。样本包括来自巴西隆德里纳的 277 名 PCa 患者和 277 名对照者。通过实时PCR分析SNP。包括 PCa 在内的癌症家族史以及受教育程度是 PCa 的危险因素。数据通过逻辑回归获得，使用 CI 95% 的优势比。AKT1 和 AKT1+AR 的基因型证明与对该疾病的保护有关。SNP 与 AMACR、AKT1+AR 等位基因变体之间的组织病理学肿瘤数据的组合 AKT1+AMACR 表明与防止精囊侵袭有关。AKT1+AR 和 PI3K+AR 多态性与对肿瘤双侧性的保护有关。基因型组合 PTEN+AMACR 和 PTEN+AR 与包膜外延伸的风险相关。在研究的五个基因中，两个与 PCa 保护相关，四个与某些预后变量的保护相关，只有一个与风险相关。因此，这些 SNP 是区分 PCa 预后更好或更差男性的候选标记。两个与 PCa 保护相关，四个与某些预后变量的保护相关，只有一个与风险相关。因此，这些 SNP 是区分 PCa 预后更好或更差男性的候选标记。两个与 PCa 保护相关，四个与某些预后变量的保护相关，只有一个与风险相关。因此，这些 SNP 是区分 PCa 预后更好或更差男性的候选标记。