Medical sheets are useful in surgically repair vascular disease. To avoid long-term side effects, they are to be replaced with regenerated tissue after implantation. Silk fibroin is a fibrous protein secreted by silkworm. The advantage of silk fibroin is its biocompatibility and has been used as regenerative artificial materials. The problem of its biodegradability is that the effect is time consuming. In this study, SVVYGLR peptide was used to expect promoting cell migration and accelerating the biodegradation of silk fibroin. Silk fibroin and polyurethane-based medical sheets with or without SVVYGLR peptide were implanted in rat abdominal aorta (silk fibroin/polyurethane/SVVYGLR peptide versus silk fibroin/polyurethane). The result of histological evaluation indicated that the new cell layer created under both sheets was composed of endothelial cells, smooth muscle, and fibroin in both sheets and similar to a native vessel. Both sheets did not show any excessive inflammation or calcification, and moderate biodegradability was observed. The decrease of silk fibroin indicated the biodegradability of all sheets. Silk fibroin/polyurethane/SVVYGLR peptide had many small vessels in the regenerated tissue than silk fibroin/polyurethane. This appearance indicated that SVVYGLR peptide promoted the angiogenesis in the regenerative tissue. This study suggested that SVVYGLR peptide could give the angiogenic-promoting activity to silk fibroin-based vascular repairing sheet.

医疗床单可用于手术修复血管疾病。为避免长期副作用，植入后将更换为再生组织。丝素蛋白是蚕分泌的一种纤维蛋白。丝素蛋白的优势在于其生物相容性，已被用作再生人造材料。其生物降解性的问题是效果耗时。在这项研究中，SVVYGLR 肽被用于预期促进细胞迁移和加速丝素蛋白的生物降解。将带有或不带有 SVVYGLR 肽的丝素蛋白和聚氨酯基医用片材植入大鼠腹主动脉（丝素蛋白/聚氨酯/SVVYGLR 肽与丝素蛋白/聚氨酯）。组织学评估结果表明，在两片下产生的新细胞层由两片中的内皮细胞、平滑肌和丝心蛋白组成，类似于天然血管。两张纸都没有显示出任何过度的炎症或钙化，并且观察到了中等的生物降解性。丝素蛋白的减少表明所有片材的生物降解性。与丝素蛋白/聚氨酯相比，丝素蛋白/聚氨酯/SVVYGLR肽在再生组织中有许多小血管。这种表现表明SVVYGLR肽促进了再生组织中的血管生成。本研究表明，SVVYGLR肽可以赋予丝素基血管修复片促血管活性。两张纸都没有显示出任何过度的炎症或钙化，并且观察到了中等的生物降解性。丝素蛋白的减少表明所有片材的生物降解性。与丝素蛋白/聚氨酯相比，丝素蛋白/聚氨酯/SVVYGLR肽在再生组织中有许多小血管。这种表现表明SVVYGLR肽促进了再生组织中的血管生成。本研究表明，SVVYGLR肽可以赋予丝素基血管修复片促血管活性。两张纸都没有显示出任何过度的炎症或钙化，并且观察到了中等的生物降解性。丝素蛋白的减少表明所有片材的生物降解性。与丝素蛋白/聚氨酯相比，丝素蛋白/聚氨酯/SVVYGLR肽在再生组织中有许多小血管。这种表现表明SVVYGLR肽促进了再生组织中的血管生成。本研究表明，SVVYGLR肽可以赋予丝素基血管修复片促血管活性。这种表现表明SVVYGLR肽促进了再生组织中的血管生成。本研究表明，SVVYGLR肽可以赋予丝素基血管修复片促血管活性。这种表现表明SVVYGLR肽促进了再生组织中的血管生成。本研究表明，SVVYGLR肽可以赋予丝素基血管修复片促血管活性。