Introduction: 

Brachial flow-mediated dilation (FMD) is a physiologic measure of endothelial function. We determined the prospective association of brachial FMD with incident dementia among older adults.

Methods: 

We included 2777 Cardiovascular Health Study participants who underwent brachial FMD measurement. Incident dementia was ascertained by medication use, International Classification of Diseases-9 codes, requirement for a proxy, and death certificates and calibrated to gold-standard assessments performed in a subset of the cohort.

Results: 

Mean participant age at time of brachial FMD measurement was 77.9 years. We identified 1650 incident dementia cases (median follow-up=10.5 y). After adjusting for age, race, sex, education, clinic site, and baseline arterial diameter, risk of dementia for participants in the highest quartile of percent brachial FMD did not differ from those in lowest quartile (hazard ratio=0.89, 95% confidence interval: 0.77, 1.03).

Conclusions: 

Brachial FMD, measured late in life, is not associated with an increased risk of incident dementia.

中文翻译：

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肱动脉血流介导的扩张和痴呆症的风险：心血管健康研究。

介绍： 

肱动脉血流介导的扩张(FMD) 是内皮功能的生理测量。我们确定了老年人中臂部 FMD 与痴呆事件的前瞻性关联。

方法： 

我们纳入了 2777 名接受过肱 FMD 测量的心血管健康研究参与者。通过药物使用、国际疾病分类 9 代码、代理要求和死亡证明来确定事件性痴呆，并校准到在队列子集中进行的金标准评估。

结果： 

测量肱 FMD 时的平均参与者年龄为 77.9 岁。我们确定了 1650例痴呆症病例（中位随访时间=10.5 年）。在调整了年龄、种族、性别、教育程度、诊所地点和基线动脉直径后，上臂 FMD 百分比最高四分位数的参与者的痴呆风险与最低四分位数的参与者没有差异（风险比 = 0.89，95% 置信区间: 0.77, 1.03)。

结论： 

在生命后期测量的肱 FMD 与痴呆症风险增加无关。