BACKGROUND While obesity is linked with brain atrophy and dementia incidence, associations with regional adiposity are uncertain. Our goal was to determine whether cerebral gray matter volume is related to neck circumference (NC), a measure of regional adiposity having unique relationships with metabolic disorders and cardiovascular disease. METHODS Magnetic resonance imaging and NC were cross-sectionally assessed from 2011 to 2014 in a population-based sample of 2916 men and women in the Korean Genome and Epidemiology Study. RESULTS For men, NC was inversely associated with total and regional gray matter in the frontal, temporal, and occipital lobes after adjusting for age and intracranial brain volume. Associations were especially strong in the presence of diabetes. With further adjustment for indices of body composition and other characteristics, total and frontal gray matter in diabetic men were lowered by 6.1 mL (95% confidence interval: 2.5-9.7, P=0.004) and 2.9 mL (95% confidence interval: 1.0-4.9, P=0.017), respectively, per SD increase in NC (2.3 cm). For men without diabetes, and in all women, associations were less apparent. CONCLUSIONS In men with diabetes, NC was inversely associated with cerebral gray matter volume. The link between neck anthropometry and brain aging in diabetic men warrants further consideration.

中文翻译：

---

颈部周长和脑灰质体积。

背景虽然肥胖与脑萎缩和痴呆发病率有关，但与局部肥胖的关联尚不确定。我们的目标是确定脑灰质体积是否与颈围 (NC) 相关，颈围是一种与代谢紊乱和心血管疾病具有独特关系的局部肥胖的量度。方法 2011 年至 2014 年，在韩国基因组和流行病学研究的 2916 名男性和女性的基于人群的样本中对磁共振成像和 NC 进行了横断面评估。结果 对于男性，在调整年龄和颅内脑容量后，NC 与额叶、颞叶和枕叶的总和区域灰质呈负相关。在存在糖尿病的情况下，相关性尤其强。随着身体成分指数和其他特征的进一步调整，糖尿病男性的总灰质和额叶灰质降低了 6.1 mL（95% 置信区间：2.5-9.7，P=0.004）和 2.9 mL（95% 置信区间：1.0- 4.9，P=0.017)，NC (2.3 cm) 的每 SD 增加。对于没有糖尿病的男性和所有女性，相关性不那么明显。结论 在患有糖尿病的男性中，NC 与脑灰质体积呈负相关。糖尿病男性颈​​部人体测量学与大脑老化之间的联系值得进一步考虑。关联不那么明显。结论 在患有糖尿病的男性中，NC 与脑灰质体积呈负相关。糖尿病男性颈​​部人体测量学与大脑衰老之间的联系值得进一步考虑。关联不那么明显。结论 在患有糖尿病的男性中，NC 与脑灰质体积呈负相关。糖尿病男性颈​​部人体测量学与大脑老化之间的联系值得进一步考虑。