The study and identification of genotype–environment interactions (GxE) has been a hot topic in the field of human genetics for several decades. Yet the extent to which GxE contributes to human behavior variability, and its mechanisms, remains largely unknown. Nick Martin has contributed important advances to the field of GxE for human behavior, which include methodological developments, novel analyses and reviews. Here, we will first review Nick’s contributions to the GxE research, which started during his PhD and consistently appears in many of his over 1000 publications. Then, we recount a project that led to an article testing the diathesis-stress model for the origins of depression. In this publication, we observed the presence of an interaction between polygenic risk scores for depression (the risk in our ‘genotype’) and stressful life events (the experiences from our ‘environment’), which provided the first empirical support of this model.

中文翻译：

---

Nick Martin 对 GxE 研究的贡献

几十年来，基因型-环境相互作用（GxE）的研究和鉴定一直是人类遗传学领域的热门话题。然而，GxE 对人类行为变异性的影响程度及其机制在很大程度上仍然未知。Nick Martin 为人类行为的 GxE 领域做出了重要贡献，其中包括方法开发、新颖的分析和评论。在这里，我们将首先回顾 Nick 对 GxE 研究的贡献，该研究始于他的博士期间，并一直出现在他的 1000 多篇出版物中。然后，我们讲述了一个项目，该项目导致了一篇测试抑郁症起源的素质压力模型的文章。在本出版物中，