Adipokines are adipocyte-secreted cell signalling proteins that travel to distant target organs and tissues, where they regulate a variety of biological actions implicated in cardiometabolic health. In the past decade, genome-wide association studies have identified multiple genetic variants associated with circulating levels of adipokines, providing new instruments for examining the role of adipokines in cardiometabolic pathologies. Currently, there is limited genetic evidence of causal relationships between adipokines and cardiometabolic disease, which is consistent with findings from randomized clinical trials that have thus far shown limited success for adipokine-based treatments in improving cardiometabolic health. Incorporating human genetic data in early phases of target selection is essential for enhancing the success of adipokine-based therapies for cardiometabolic disease.

中文翻译：

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遗传变异、脂肪因子和心脏代谢疾病。

脂肪因子是脂肪细胞分泌的细胞信号蛋白，可传播到远处的目标器官和组织，在那里它们调节与心脏代谢健康有关的各种生物作用。在过去十年中，全基因组关联研究已经确定了与脂肪因子循环水平相关的多种遗传变异，为检查脂肪因子在心脏代谢病理学中的作用提供了新的工具。目前，脂肪因子与心脏代谢疾病之间因果关系的遗传证据有限，这与随机临床试验的结果一致，迄今为止，基于脂肪因子的治疗在改善心脏代谢健康方面取得的成功有限。