Ghrelin is a stomach-derived hormone and a potent appetite stimulant. Ghrelin has recently harbored interest as a potential regulator of carbohydrate and lipid metabolism in skeletal muscle and adipose tissue; however, in vivo ghrelin administration is confounded by secondary effects. The assessment of the direct metabolic effects of acylated (AG) and unacylated (UnAG) ghrelin is a relatively new area of research. In isolated adipocytes and muscle, ghrelin has demonstrated antilipolytic effects. In muscle, ghrelin has been shown to acutely stimulate fat oxidation, which may protect the muscle from the insulin-desensitizing effects of high fatty acid concentrations. The effects of ghrelin directly on muscle glucose uptake are controversial. Whether ghrelin can be utilized therapeutically for conditions such as type 2 diabetes will depend on our better understanding of ghrelin's independent effects on muscle and adipose tissue metabolism, and whether this can predict ghrelin's effects when administered in vivo.

中文翻译：

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胃源性激素生长素释放肽对脂肪组织和骨骼肌底物代谢的调节。

Ghrelin 是一种胃源性激素，也是一种有效的食欲刺激剂。Ghrelin 最近作为骨骼肌和脂肪组织中碳水化合物和脂质代谢的潜在调节剂引起了人们的兴趣。然而，体内 ghrelin 给药会受到继发效应的影响。对酰化 (AG) 和非酰化 (UnAG) ghrelin 的直接代谢作用的评估是一个相对较新的研究领域。在分离的脂肪细胞和肌肉中，生长素释放肽已显示出抗脂解作用。在肌肉中，生长素释放肽已被证明能强烈刺激脂肪氧化，这可能会保护肌肉免受高脂肪酸浓度的胰岛素脱敏作用。ghrelin 对肌肉葡萄糖摄取的直接影响是有争议的。