Browning of white adipose tissue is a cold-induced phenomenon in rodents, constituted by the differentiation of a subset of thermogenic adipocytes among existing white adipocytes. Emerging evidence in the literature points at additional factors and environmental conditions stimulating browning in rodents, including physical exercise training. Exercise engages sympathetic activation which during cold activation promotes proliferation and differentiation of brown preadipocytes. Exercise also stimulates the release of multiple growth factors and cytokines. Importantly, there are clear discrepancies between human and rodents with regard to thermogenic capacity and browning potential. Here we provide a translational perspective on exercise-induced browning and review recent findings on the role of myokines and hepatokines in this process.

中文翻译：

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白色脂肪组织的运动和褐变 - 平移视角。

白色脂肪组织的褐变是啮齿类动物的冷诱导现象，由现有白色脂肪细胞中的一部分产热脂肪细胞分化构成。文献中的新证据指出了刺激啮齿动物褐变的其他因素和环境条件，包括体育锻炼。运动参与交感神经激活，在冷激活期间促进棕色前脂肪细胞的增殖和分化。运动还能刺激多种生长因子和细胞因子的释放。重要的是，人类和啮齿动物在产热能力和褐变潜力方面存在明显差异。在这里，我们提供了一个关于运动引起的褐变的转化观点，并回顾了最近关于肌因子和肝因子在这个过程中的作用的发现。