Legalization of Cannabis in countries, like Canada, and global demand for non-hallucinating chemical components, such as Cannabidiols (CBD), have stimulated the increased interest from academics, industry, and regulatory agencies. Subsequent research publications in scientific journals in this field are expected to grow rapidly. However, there have been few research reviews that have quantified patterns in research publications concerning cannabis, nor a literature-based perspective on the historical development, current status, and future direction of cannabis research. Here, a bibliometric analysis is performed to address this gap in the scientific literature. A total of 1167 relevant articles (Supplementary file 1) were screened and analyzed using three software tools: HistCite, CiteSpace, and Bibliometric Online Analysis Platform. The performances of relevant countries, institutions, authors, and journals were presented, and the evolutionary trends of different categories were revealed. The historical development of cannabis and CBD research can be clearly divided into three stages, which focus on the chemistry, pharmacology, and molecular biology aspects of Cannabis sativa in general and then a focus on CBD related publications. A timeline was drawn to highlight the major trends in the literature, including scientific discoveries. In the end, several suggestions for future research directions in this field are provided.

加拿大等国家/地区的大麻合法化，以及对大麻素等非卤化化学成分的全球需求，激发了学术界，行业和监管机构的浓厚兴趣。预计该领域随后在科学期刊中的研究出版物将迅速增长。但是，很少有研究评论量化了有关大麻的研究出版物中的模式，也没有关于大麻研究的历史发展，现状和未来方向的基于文献的观点。在这里，进行文献计量分析以解决科学文献中的这一空白。总共使用3种软件工具筛选和分析了1167条相关文章（补充文件1）：HistCite，CiteSpace和Bibliometric在线分析平台。介绍了相关国家，机构，作者和期刊的表现，并揭示了不同类别的演变趋势。大麻的历史发展和CBD的研究可以分为三个阶段，主要集中在大麻的化学，药理学和分子生物学方面，然后集中在与CBD有关的出版物上。绘制了一个时间表，以强调文学的主要趋势，包括科学发现。最后，为该领域的未来研究方向提供了一些建议。该指南主要关注大麻的化学，药理学和分子生物学方面，然后关注与CBD有关的出版物。绘制了一个时间表，以强调文学的主要趋势，包括科学发现。最后，为该领域的未来研究方向提供了一些建议。该指南主要关注大麻的化学，药理学和分子生物学方面，然后关注与CBD有关的出版物。绘制了一个时间表，以强调文学的主要趋势，包括科学发现。最后，为该领域的未来研究方向提供了一些建议。