The jugular ganglion (JG) contains sensory neurons of the vagus nerve which innervate somatic and visceral structures in cranial and cervical regions. In this study, the number of sensory neurons in the human JG was investigated. And, the morphology of sensory neurons in the human JG and nodose ganglion (NG) was compared. The estimated number of JG neurons was 2721.8-9301.1 (average number of sensory neurons ± S.D. = 7975.1 ± 3312.8). There was no significant difference in sizes of the neuronal cell body and nucleus within the JG (cell body, 1128.8 ± 99.7 μ m2; nucleus, 127.7 ± 20.8 μ m2) and NG (cell body, 963.8 ± 225.7 μ m2; nucleus, 123.2 ± 32.3 μ m2). These findings indicate that most of sensory neurons show the similar morphology in the JG and NG. Our immunohistochemical method also demonstrated the distribution of ion channels, neurotransmitter agents and calcium-binding proteins in the human JG. Numerous JG neurons were immunoreactive for transient receptor potential cation channel subfamily V member 1 (TRPV1, mean ± SD = 19.9 ± 11.5 %) and calcitonin gene-related peptide (CGRP, 28.4 ± 6.7 %). A moderate number of JG neurons contained TRPV2 (12.0 ± 4.7 %), substance P (SP, 15.7 ± 6.9 %) and secreted protein, acidic and rich in cysteine-like 1 (SPARCL1, 14.6 ± 7.4 %). A few JG neurons had vesicular glutamate transporter 2 (VGLUT2, 5.6 ± 2.9 %) and parvalbumin (PV, 2.3 ± 1.4 %). SP- and TRPV2-containing JG neurons had mainly small and medium-sized cell bodies, respectively. TRPV1- and VGLUT2- containing JG neurons were small to medium-sized. CGRP- and SPARCL1-containing JG neurons were of various cell body sizes. Sensory neurons in the human JG were mostly free of vasoactive intestinal polypeptide (VIP), tyrosine hydroxylase (TH) and neuropeptide Y (NPY). In the external auditory canal skin, subepithelial nerve fibers contained TRPV1, TRPV2, SP, CGRP and VGLUT2. Perivascular nerve fibers also had TRPV1, TRPV2, SP, CGRP, VIP, NPY and TH. However, PV- and SPARCL1-containing nerve endings could not be seen in the external auditory canal. It is likely that sensory neurons in the human JG can transduce nociceptive and mechanoreceptive information from the external auditory canal. Theses neurons may be also associated with neurogenic inflammation in the external auditory canal and ear-cough reflex through the vagus nerve.

中文翻译：

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人颈神经节中的感觉神经元。

颈神经节（JG）包含迷走神经的感觉神经元，这些神经神经支配颅和颈区域的躯体和内脏结构。在这项研究中，调查了人类JG中感觉神经元的数量。并且，比较了人类JG和结节神经节（NG）中感觉神经元的形态。JG神经元的估计数量为2721.8-9301.1（感觉神经元的平均数量±SD = 7975.1±3312.8）。JG（细胞体，1128.8±99.7μm2;核，127.7±20.8μm2）和NG（细胞体，963.8±225.7μm2;核，123.2）内神经元细胞体和细胞核的大小没有显着差异±32.3μm2）。这些发现表明，大多数感觉神经元在JG和NG中表现出相似的形态。我们的免疫组织化学方法还证明了离子通道的分布，人JG中的神经递质和钙结合蛋白。许多JG神经元对瞬时受体电位阳离子通道亚家族V成员1（TRPV1，平均值±SD = 19.9±11.5％）和降钙素基因相关肽（CGRP，28.4±6.7％）具有免疫反应性。中等数量的JG神经元包含TRPV2（12.0±4.7％），P物质（SP，15.7±6.9％）和分泌的蛋白质，呈酸性，富含半胱氨酸样1（SPARCL1，14.6±7.4％）。少数JG神经元具有水泡谷氨酸转运蛋白2（VGLUT2，5.6±2.9％）和小白蛋白（PV，2.3±1.4％）。含有SP和TRPV2的JG神经元分别主要具有中小型细胞体。含有TRPV1和VGLUT2的JG神经元大小不一。含有CGRP和SPARCL1的JG神经元具有各种细胞体大小。人JG中的感觉神经元大部分不含血管活性肠多肽（VIP），酪氨酸羟化酶（TH）和神经肽Y（NPY）。在外耳道皮肤中，上皮下神经纤维含有TRPV1，TRPV2，SP，CGRP和VGLUT2。血管周围神经纤维还具有TRPV1，TRPV2，SP，CGRP，VIP，NPY和TH。但是，在外耳道中看不到含有PV和SPARCL1的神经末梢。人类JG中的感觉神经元很可能可以转换外耳道的伤害性和机械感受性信息。这些神经元也可能与外耳道的神经源性炎症和迷走神经的耳咳反射有关。上皮下神经纤维包含TRPV1，TRPV2，SP，CGRP和VGLUT2。血管周围神经纤维还具有TRPV1，TRPV2，SP，CGRP，VIP，NPY和TH。但是，在外耳道中看不到含有PV和SPARCL1的神经末梢。人类JG中的感觉神经元很可能可以转导来自外耳道的伤害性和机械感受性信息。这些神经元也可能与外耳道的神经源性炎症和迷走神经的耳咳反射有关。上皮下神经纤维包含TRPV1，TRPV2，SP，CGRP和VGLUT2。血管周围神经纤维还具有TRPV1，TRPV2，SP，CGRP，VIP，NPY和TH。但是，在外耳道中看不到含有PV和SPARCL1的神经末梢。人类JG中的感觉神经元很可能可以转换外耳道的伤害性和机械感受性信息。这些神经元也可能与外耳道的神经源性炎症和迷走神经的耳咳反射有关。人类JG中的感觉神经元很可能可以转换外耳道的伤害性和机械感受性信息。这些神经元也可能与外耳道的神经源性炎症和迷走神经的耳咳反射有关。人类JG中的感觉神经元很可能可以转导来自外耳道的伤害性和机械感受性信息。这些神经元也可能与外耳道的神经源性炎症和迷走神经的耳咳反射有关。