Flip-flop asymmetry of cholesterol in model membranes induced by thermal gradients.,Soft Matter

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Flip-flop asymmetry of cholesterol in model membranes induced by thermal gradients.
Soft Matter ( IF 2.9 ) Pub Date : 2020-06-08 , DOI: 10.1039/d0sm00546k
James W Carter ₁ , Miguel A Gonzalez , Nicholas J Brooks , John M Seddon , Fernando Bresme

Affiliation

Lipid asymmetry is a crucial property of biological membranes and significantly influences their physical and mechanical properties. It is responsible for maintaining different chemical environments on the external and internal surfaces of cells and organelles and plays a vital role in many biological processes such as cell signalling and budding. In this work we show, using non-equilibrium molecular dynamics (NEMD) simulations, that thermal fields can induce lipid asymmetry in biological membranes. We focus our investigation on cholesterol, an abundant lipid in the plasma membrane, with a rapid flip-flop rate, significantly influencing membrane properties. We demonstrate that thermal fields induce membrane asymmetry with cholesterol showing thermophobic behaviour and therefore accumulating on the cold side of the membrane. This work highlights a possible experimental route to preparing and controlling asymmetry in synthetic membranes.

中文翻译：

由热梯度引起的模型膜中胆固醇的触发器不对称性。

脂质不对称性是生物膜的关键特性，并显着影响其物理和机械性能。它负责维持细胞和细胞器内外表面上不同的化学环境，并且在许多生物过程（例如细胞信号传导和出芽）中起着至关重要的作用。在这项工作中，我们显示了使用非平衡分子动力学（NEMD）模拟，热场可以在生物膜中引起脂质不对称。我们将研究重点放在胆固醇（一种质膜中的丰富脂质），快速翻转速率，显着影响膜性能的方面。我们证明了热场诱导膜不对称性与胆固醇表现出嗜热行为，因此积累在膜的冷侧。

更新日期：2020-07-01

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