Manganese(iii)-promoted tandem phosphinoylation/cyclization of 2-arylindoles/2-arylbenzimidazoles with disubstituted phosphine oxides.,Organic & Biomolecular Chemistry

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Manganese(iii)-promoted tandem phosphinoylation/cyclization of 2-arylindoles/2-arylbenzimidazoles with disubstituted phosphine oxides.
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-06-08 , DOI: 10.1039/d0ob00877j
Shuai-Shuai Jiang ₁ , Yu-Ting Xiao ₁ , Yan-Chen Wu ₁ , Shu-Zheng Luo ₁ , Ren-Jie Song ₁ , Jin-Heng Li ₂

Affiliation

A simple and practical method for the synthesis of phosphoryl-substituted indolo[2,1-a]isoquinolin-6(5H)-ones and benzimidazo[2,1-a]isoquinolin-6(5H)-ones through manganese(III)-promoted tandem phosphinoylation/cyclization of 2-arylindoles or 2-arylbenzimidazoles with disubstituted phosphine oxides was developed. In this transformation, new C–P bond and C–C bond were constructed simultaneously under silver-free conditions, exhibiting a broad substrate scope. It was noted that not only diarylphosphine oxides but also dialkyl and arylalkyl-phosphine oxides were compatible with the conditions.

中文翻译：

锰（iii）促进双取代膦氧化物对2-芳基吲哚/ 2-芳基苯并咪唑的串联膦酰基化/环化反应。

一种简单实用的方法，通过锰合成磷酸取代的吲哚[2,1 - a ]异喹啉-6（5 H）-和苯并咪唑[2,1 - a ]异喹啉-6（5 H）-。III）促进了双芳基膦酸酯或2-芳基苯并咪唑与双取代氧化膦的串联膦酰基化/环化反应。在这种转变中，在无银条件下同时构建了新的C–P键和C–C键，具有广泛的底物范围。注意到不仅二芳基膦氧化物，而且二烷基和芳基烷基膦氧化物也符合条件。

更新日期：2020-07-01

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