Pyrroloquinoline quinone (PQQ), present in breast milk and various foods, is highly recommended as an antioxidant, anti-inflammatory agent, and a cofactor in redox reactions in several biomedical fields. Moreover, PQQ has neuroprotective effects on nervous system disorders and immunosuppressive effects on different diseases. Herein, we report on the optimum fabrication of electrospun CS/PVA coaxial, core/shell, and uniaxial nanofibers. The morphological, elemental, and chemical structure of the fabricated nanofibers were investigated and discussed. PQQ, as a drug, was loaded on the uniaxial nanofibers and in the core of the coaxial nanofibers and the sustained and controlled release of PQQ was compared and discussed. The results revealed the privilege of the coaxial over the uniaxial nanofibers in the sustained release and reduction of the initial burst of PQQ. Remarkably, the results revealed a higher degree of swelling for CS/PVA hollow nanofibers compared to that of the uniaxial and the coaxial nanofibers. The coaxial nanofibers showed a lower release rate than the uniaxial nanofibers. Moreover, the CS/PVA coaxial nanofibers loaded with PQQ were found to enhance cell viability and proliferation. Therefore, the CS/PVA coaxial nanofibers loaded with PQQ assembly is considered a superior drug delivery system for PQQ release.

中文翻译：

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同轴纳米纤维在装载和释放用于生物医学应用的吡咯并喹啉醌 (PQQ) 方面优于单轴纳米纤维

吡咯喹啉醌 (PQQ) 存在于母乳和各种食物中，在多个生物医学领域被强烈推荐作为抗氧化剂、抗炎剂和氧化还原反应的辅助因子。此外，PQQ 对神经系统疾病具有神经保护作用，对不同疾病具有免疫抑制作用。在此，我们报告了电纺 CS/PVA 同轴、核/壳和单轴纳米纤维的最佳制造。研究和讨论了制造的纳米纤维的形态、元素和化学结构。PQQ作为药物负载于单轴纳米纤维和同轴纳米纤维的核心，比较和讨论了PQQ的缓控释。结果揭示了同轴纳米纤维在持续释放和减少 PQQ 的初始爆发方面优于单轴纳米纤维。值得注意的是，结果表明，与单轴和同轴纳米纤维相比，CS/PVA 中空纳米纤维的溶胀度更高。同轴纳米纤维的释放速率低于单轴纳米纤维。此外，发现负载有 PQQ 的 CS/PVA 同轴纳米纤维可增强细胞活力和增殖。因此，装载有 PQQ 组件的 CS/PVA 同轴纳米纤维被认为是一种用于 PQQ 释放的优良药物输送系统。同轴纳米纤维的释放速率低于单轴纳米纤维。此外，发现负载有 PQQ 的 CS/PVA 同轴纳米纤维可增强细胞活力和增殖。因此，装载有 PQQ 组件的 CS/PVA 同轴纳米纤维被认为是一种用于 PQQ 释放的优良药物输送系统。同轴纳米纤维的释放速率低于单轴纳米纤维。此外，发现负载有 PQQ 的 CS/PVA 同轴纳米纤维可增强细胞活力和增殖。因此，装载有 PQQ 组件的 CS/PVA 同轴纳米纤维被认为是一种用于 PQQ 释放的优良药物输送系统。