Background:

The widespread use of synthetic cannabinoids (SCs) among youth has become an important public health problem. Several life-threatening side effects of SC have been reported, including cardiovascular, gastrointestinal, neurological, renal, metabolic, ophthalmologic, and pulmonary effects, besides skin toxicity and hepatotoxicity.

Methods:

Given that high levels of SC can lead to oxidative stress, DNA damage, and inflammation, it has been aimed in this study to investigate the effects of SC in aspects of primary DNA damage, plasma total oxidant status (TOS)/total antioxidant status (TAS), thiol–disulfide homeostasis, myeloperoxidase (MPO) level, and cytokine levels (interleukin 1 beta (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-α)) of 40 SC users (SCUs) in Turkey.

Results:

Mean plasma TOS levels were significantly higher in the SCUs group than in the healthy group (HG). Similarly, mononuclear leukocyte DNA damage, plasma TOS, MPO activity, disulfide, oxidative stress index levels, IL-1β, IL-6, and TNF-α levels were significantly higher in the SCU group than in the HG, whereas plasma TAS, total, and native thiol levels were significantly lower in the SCU group than in the HG.

Conclusion:

It is concluded that SC can cause increase in oxidative stress and in inflammatory processes in addition to its potential for DNA damage. Additional studies with larger sample sizes and longer durations should be held to understand more specific outcomes of SC use.

中文翻译：

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研究合成大麻素使用者的 DNA 损伤、氧化应激和炎症。

背景：

合成大麻素 (SCs) 在青少年中的广泛使用已成为一个重要的公共卫生问题。除了皮肤毒性和肝毒性外，已经报道了 SC 的几种危及生命的副作用，包括心血管、胃肠道、神经系统、肾脏、代谢、眼科和肺部影响。

方法：

鉴于高水平的 SC 可导致氧化应激、DNA 损伤和炎症，本研究旨在调查 SC 在原发性 DNA 损伤、血浆总氧化状态 (TOS)/总抗氧化状态方面的影响。 40 SC土耳其的用户 (SCU)。

结果：

SCUs组的平均血浆TOS水平显着高于健康组（HG）。同样，SCU 组的单核白细胞 DNA 损伤、血浆 TOS、MPO 活性、二硫化物、氧化应激指数水平、IL-1β、IL-6 和 TNF-α 水平显着高于 HG，而血浆 TAS、总, SCU 组的天然硫醇水平显着低于 HG。

结论：

得出的结论是，SC 除了可能造成 DNA 损伤外，还可能导致氧化应激和炎症过程的增加。应进行更多样本量更大、持续时间更长的研究，以了解 SC 使用的更具体结果。