Thermo-responsive Polysaccharide Graft Polymer Vesicles with Tunable Size and Structural Memory,Journal of the American Chemical Society

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Thermo-responsive Polysaccharide Graft Polymer Vesicles with Tunable Size and Structural Memory
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2020-06-08 , DOI: 10.1021/jacs.0c02290
Tomoki Nishimura ₁ , Shen Shishi ₁ , Yoshihiro Sasaki ₁ , Kazunari Akiyoshi ₁

Affiliation

Controlling polymer vesicle size is difficult and a major obstacle for their potential use in biomedical applications, such as drug delivery carriers and nanoreactors. Herein, we report size-tunable polymer vesicles based on self-assembly of a thermo-responsive amphiphilic graft copolymer. Unilamellar polymer vesicles form upon heating chilled polymer solutions, and vesicle size can be tuned in the range of 40-70 nm by adjusting the initial polymer concentration. Notably, the polymer can reversibly switch between a monomer state and vesicle state in accordance with a cooling/heating cycle, which changes neither the size nor size distribution of the vesicles. This lack of change suggests that the polymer memorizes a particular vesicle conformation. Given our vesicles' size tunability and structural memory, our research considerably expands the fundamental and practical scope of thermo-responsive amphiphilic graft copolymers, and renders amphiphilic graft copolymers useful tools for synthesizing functional self-assembled materials.

中文翻译：

具有可调尺寸和结构记忆的热响应多糖接枝聚合物囊泡

控制聚合物囊泡的大小是困难的，并且是它们在生物医学应用（例如药物递送载体和纳米反应器）中潜在用途的主要障碍。在此，我们报告了基于热响应两亲接枝共聚物的自组装的尺寸可调的聚合物囊泡。加热冷却的聚合物溶液时会形成单层聚合物囊泡，并且可以通过调整初始聚合物浓度在 40-70 nm 范围内调整囊泡大小。值得注意的是，聚合物可以根据冷却/加热循环在单体状态和囊泡状态之间可逆地转换，这既不改变囊泡的大小也不改变大小分布。这种缺乏变化表明聚合物记忆了特定的囊泡构象。鉴于我们囊泡的大小可调性和结构记忆，

更新日期：2020-06-08

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