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Mesoporous Silica Nanoparticles at Predicted Environmentally Relevant Concentrations Cause Impairments in GABAergic Motor Neurons of Nematode Caenorhabditis elegans.
Chemical Research in Toxicology ( IF 3.7 ) Pub Date : 2020-06-08 , DOI: 10.1021/acs.chemrestox.9b00477
Xue Liang 1 , Yutong Wang 1 , Jin Cheng 1 , Qianqian Ji 1 , Yan Wang 1 , Tianshu Wu 1 , Meng Tang 1
Affiliation  

Available safety evaluations regarding mesoporous silica nanoparticles (mSiNPs) are based on the assumption of a relatively high exposure concentration, which makes the findings less valuable in a realistic environment. In this study, we employed Caenorhabditis elegans (C. elegans) as a model to assess the neuronal damage caused by mSiNPs at the predicted environmentally relevant concentrations. After nematodes were acute and prolonged exposed to mSiNPs at concentrations over 300 μg/L, locomotion degeneration, shrinking behavior, and abnormal foraging behavior were observed, which were associated with the deficits in the development of GABAergic neurons, including D-type and RME motor neurons. Furthermore, the oxidative stress evidenced by excessive ROS generation might contribute to the mechanism of mSiNPs damaging neurons. Although the neurotoxicity of mSiNPs was weaker than (nonmesoporous) SiNPs, it is still necessary for researchers to pay attention to the adverse effects caused by mSiNPs in the environmental animals, especially with the rapid increase in mSiNPs application. Considering the conserved property of GABAergic neurons during evolution, these findings will shed light on our understanding of the potential eco-risks of NPs to the nervous system of other animal models.

中文翻译:

介孔二氧化硅纳米颗粒在与环境相关的预期浓度下会导致线虫秀丽隐杆线虫的GABA能运动神经元受损。

关于介孔二氧化硅纳米粒子(mSiNPs)的可用安全性评估是基于相对较高的暴露浓度的假设,这使得该发现在现实环境中的价值降低。在这项研究中,我们采用了秀丽隐杆线虫C. elegans)作为评估在预期的环境相关浓度下mSiNPs引起的神经元损伤的模型。线虫急性发作并长时间暴露于浓度超过300μg/ L的mSiNPs后,观察到运动变性,收缩行为和异常觅食行为,这与GABA能神经元发育的缺陷有关,包括D型和RME运动神经元。此外,由过量ROS产生所证明的氧化应激可能有助于mSiNPs破坏神经元的机制。尽管mSiNPs的神经毒性比(非中晚期)SiNPs弱,但是研究人员仍然需要注意mSiNPs对环境动物的不利影响,尤其是随着mSiNPs应用的迅速增加。
更新日期:2020-07-20
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