Some interesting properties such as superelasticity, shape memory effect, kink resistance, good biocompatibility, biomechanical properties, and corrosion resistance made nitinol a popular biomaterial as stent and orthopedic implants. But surface modification is needed to control nickel leaching from its surface, making safe for human body. The aim of this study was to modify the nitinol surface by the silanization technique and electrophoretically deposited hydroxyapatite coating, and to conduct a detailed in vitro and in vivo investigation. Detailed in vitro investigation involved MTT assay with the human osteoblastic cells (MG63 cell) over a period of 5 days and confocal image study. In case of in vivo study, histological study, fluorochrome labeling study, and Micro-Ct study were conducted. The overall in vitro and in vivo results indicate that silanized nitinol samples are showing slightly better level of performance, but both the surface-modified samples are suitable as the potential bio-implant for orthopedic purpose.

镍钛诺具有一些有趣的特性，例如超弹性，形状记忆效应，抗扭结性，良好的生物相容性，生物力学特性和耐腐蚀性，从而使镍钛诺成为了一种受欢迎的生物材料，可用作支架和整形外科植入物。但是需要进行表面改性以控制镍从表面的浸出，从而对人体安全。这项研究的目的是通过硅烷化技术和电泳沉积的羟基磷灰石涂层修饰镍钛合金表面，并进行详细的体外和体内研究。详细的体外研究包括在5天的时间内用人成骨细胞（MG63细胞）进行MTT分析和共聚焦图像研究。在体内研究的情况下，进行了组织学研究，荧光染料标记研究和Micro-Ct研究。