Marine-derived bacteria are a prolific source of a wide range of structurally diverse natural products. This review, dedicated to Professor William Fenical, begins by showcasing many seminal discoveries made at the University of California San Diego from marine-derived actinomycetes. Discussed early on is the 20-year journey of discovery and advancement of the seminal actinomycetes natural product salinosporamide A into Phase III anticancer clinical trials. There are many fascinating parallels discussed that were gleaned from the comparative literature of marine sponge, tunicate, and bacteria-derived natural products. Identifying bacterial biosynthetic machinery housed in sponge and tunicate holobionts through both culture-independent and culture-dependent approaches is another important and expanding subject that is analyzed. Work reviewed herein also evaluates the hypotheses that many marine invertebrate-derived natural products are biosynthesised by associated or symbiotic bacteria. The insights and outcomes from metagenomic sequencing and synthetic biology to expand molecule discovery continue to provide exciting outcomes and they are predicted to be the source of the next generation of novel marine natural product chemical scaffolds.

海洋源性细菌是多种结构多样的天然产物的丰富来源。这篇评论是献给 William Fenical 教授的，首先展示了加州大学圣地亚哥分校从海洋衍生的放线菌中取得的许多开创性发现。早期讨论的是发现和推进精放线菌天然产物盐孢菌胺 A 进入 III 期抗癌临床试验的 20 年历程。从海绵、被囊类动物和细菌衍生的天然产物的比较文献中收集到许多有趣的相似之处。通过不依赖于培养和依赖于培养的方法识别海绵和被囊类全生物中的细菌生物合成机制是另一个重要且不断扩展的主题。本文回顾的工作还评估了许多海洋无脊椎动物衍生的天然产物由相关或共生细菌生物合成的假设。宏基因组测序和合成生物学扩大分子发现的见解和成果继续提供令人兴奋的成果，预计它们将成为下一代新型海洋天然产物化学支架的来源。