Noncoding RNAs (ncRNAs) direct a remarkable number of diverse functions in development and disease through their regulation of transcription, RNA processing and translation. Leading the charge in the RNA revolution is a class of ncRNAs that are synthesized at active enhancers, called enhancer RNAs (eRNAs). Here, we review recent insights into the biogenesis of eRNAs and the mechanisms underlying their multifaceted functions and consider how these findings could inform future investigations into enhancer transcription and eRNA function.

中文翻译：

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增强子RNA是表观基因组的重要调控层。

非编码RNA（ncRNA）通过调节转录，RNA加工和翻译来指导发育和疾病中的多种功能。在RNA革命中引领潮流的是一类在活性增强子（称为增强子RNA（eRNA））上合成的ncRNA。在这里，我们回顾了有关eRNA的生物发生及其潜在功能的机制的最新见解，并考虑了这些发现如何为将来有关增强子转录和eRNA功能的研究提供信息。