Experimental approaches have been applied to address questions in understanding three-dimensional chromatin organization and function. As datasets increase in size and complexity, it becomes a challenge to reach a mechanistic interpretation of experimental results. Polymer simulations and mechanistic modeling have been applied to explain experimental observations and their links to different aspects of genome function. Here we provide a guide for biologists, explaining different simulation approaches and the contexts in which they have been used.

中文翻译：

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染色质折叠的机械建模以了解功能。

实验方法已用于解决理解三维染色质组织和功能的问题。随着数据集的大小和复杂性的增加，对实验结果进行机械解释成为一个挑战。聚合物模拟和机理建模已被用于解释实验观察及其与基因组功能不同方面的联系。在这里，我们为生物学家提供了指南，解释了不同的仿真方法以及使用它们的环境。