Study Design

Prospective longitudinal cohort study

Background

Adolescent athletes may be more susceptible to the long-term effects of mild traumatic brain injury (mTBI). A diagnostic and prognostic neuromarker may optimize management and return-to-activity decision-making in athletes who experience mTBI.

Objective

Measure an event-related potential (ERP) component captured with electroencephalography (EEG), called processing negativity (PN), at baseline and post-injury in adolescents who suffered mTBI and determine their longitudinal response relative to healthy controls.

Methods

Thirty adolescents had EEG recorded during an auditory oddball task at a pre-mTBI baseline session and subsequent post-mTBI sessions. Longitudinal EEG data from patients and healthy controls (n= 77) were obtained from up to four sessions in total and processed using Brain Network Analysis algorithms.

Results

The average PN amplitude in healthy controls significantly decreased over sessions 2 and 3; however, it remained steady in the mTBI group’s 2nd (post-mTBI) session and decreased only in sessions 3 and 4. Pre- to post-mTBI amplitude changes correlated with the time interval between sessions.

Conclusion

These results demonstrate that PN amplitude changes may be associated with mTBI exposure and subsequent recovery in adolescent athletes. Further study of PN may lead to it becoming a neuromarker for mTBI prognosis and return-to-activity decision-making in adolescents.

中文翻译：

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前瞻性纵向调查显示，事件相关潜力与青少年轻度脑外伤相关。

学习规划

前瞻性纵向队列研究

背景

青少年运动员可能更容易受到轻度脑外伤（mTBI）的长期影响。诊断和预后神经标志物可以优化经历mTBI的运动员的管理和恢复活动的决策。

目的

在患mTBI的青少年中，在基线和受伤后测量脑电图（EEG）捕获的事件相关电位（ERP）成分，称为过程负电性（PN），并确定其相对于健康对照的纵向反应。

方法

30名青少年在mTBI之前的基线会议和随后的mTBI之前的会议进行听觉怪异任务期间记录了脑电图。从患者和健康对照者（n = 77）的纵向EEG数据总共总共获取了四个疗程，并使用Brain Network Analysis算法进行了处理。

结果

在第2和3阶段，健康对照组的平均PN幅度明显降低；但是，它在mTBI组的第二个（mTBI之后）会话中保持稳定，并且仅在第3和4个会话中减小。mTBI之前到之后的幅度变化与会话之间的时间间隔相关。

结论

这些结果表明，PN幅度变化可能与青少年运动员的mTBI暴露和随后的恢复有关。对PN的进一步研究可能使其成为青少年mTBI预后和活动决策的神经标记。