Abstract

Circadian rhythm is a universal life phenomenon that plays an important role in maintaining the multiple physiological functions and regulating the adaptability to internal and external environments of flora and fauna. Circadian alignment in humans has the greatest effect on human health, and circadian misalignment is closely associated with increased risk for metabolic syndrome, cardiovascular diseases, neurological diseases, immune diseases, cancer, sleep disorders, and ophthalmic diseases. The recent description of clock proteins and related post-modification targets was involved in several diseases, and numerous lines of evidence are emerging that small molecule modulators of circadian rhythms can be used to rectify circadian disorder. Herein, we attempt to update the disclosures about the modulators targeting core clock proteins and related post-modification targets, as well as the relationship between circadian rhythm disorders and human health as well as the therapeutic role and prospect of these small molecule modulators in circadian rhythm related disease.

摘要

昼夜节律是一种普遍的生命现象，对于维持动植物的多种生理功能、调节对内外环境的适应能力发挥着重要作用。人体的昼夜节律调整对人类健康影响最大，昼夜节律失调与代谢综合征、心血管疾病、神经系统疾病、免疫疾病、癌症、睡眠障碍和眼科疾病的风险增加密切相关。最近对时钟蛋白和相关后修饰靶点的描述涉及多种疾病，并且大量证据表明昼夜节律的小分子调节剂可用于纠正昼夜节律紊乱。在此，我们尝试更新针对核心时钟蛋白的调节剂及相关修饰后靶点的披露，以及昼夜节律紊乱与人类健康的关系以及这些小分子调节剂在昼夜节律中的治疗作用和前景。相关疾病。