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Neuregulin 1 (NRG-1) as a neuronal active substance in the porcine intrahepatic nerve fibers in physiological conditions and under the influence of bisphenol A (BPA)
Annals of Animal Science ( IF 1.8 ) Pub Date : 2020-06-05 , DOI: 10.2478/aoas-2020-0038
Liliana Rytel 1 , Marcelo Alarcón Lozano 2 , Slawomir Gonkowski 3
Affiliation  

Abstract Bisphenol A (BPA ) is a substance commonly used in the production of plastics. Previous studies have described that it shows multidirectional harmful effects on the living organism. It is known that BPA causes liver damage, but knowledge about the roles of intrahepatic nerves in these mechanisms is extremely scanty. On the other hand, the exact roles of some neuronal substances in the nervous structures located in the liver still remain unknown. One of such substance, which is allocated a role in the stimulation of cell survival is neuregulin 1 (NRG-1). The aim of the present study was to investigate the distribution of NRG-1-like immunoreactive (NRG-1-LI) nerves in the liver in physiological conditions and under the influence of various doses of BPA using routine double immunofluorescence staining. The results (for the first time) show the presence of NRG-1 in the intrahepatic nerves, and co-localization of NGR-1 with neuronal isoform of nitric oxide synthase (nNOS) and vasoactive intestinal polypeptide (VIP). Moreover, it has been observed that high doses of BPA increase the density of NRG-1-LI intrahepatic nerves and the degree of co-localization of NRG-1 with VIP. These observations suggest that NRG-1 located in intrahepatic nerves may play functions in processes connected with liver damage and/or regeneration under the impact of BPA.

中文翻译:

Neuregulin 1 (NRG-1) 作为猪肝内神经纤维中的神经元活性物质,在生理条件和双酚 A (BPA) 的影响下

摘要 双酚A(BPA)是塑料生产中常用的一种物质。先前的研究表明,它对生物体显示出多方面的有害影响。众所周知,双酚 A 会导致肝损伤,但关于肝内神经在这些机制中的作用的知识非常少。另一方面,一些神经元物质在位于肝脏的神经结构中的确切作用仍然未知。神经调节蛋白 1 (NRG-1) 是其中一种在刺激细胞存活中发挥作用的物质。本研究的目的是使用常规双免疫荧光染色研究生理条件下和不同剂量 BPA 影响下肝脏中 NRG-1 样免疫反应 (NRG-1-LI) 神经的分布。结果(首次)显示肝内神经中存在 NRG-1,并且 NGR-1 与一氧化氮合酶 (nNOS) 和血管活性肠多肽 (VIP) 的神经元同种型共定位。此外,已经观察到高剂量的 BPA 会增加 NRG-1-LI 肝内神经的密度以及 NRG-1 与 VIP 的共定位程度。这些观察结果表明,位于肝内神经的 NRG-1 可能在 BPA 影响下与肝损伤和/或再生相关的过程中发挥作用。已经观察到高剂量的 BPA 会增加 NRG-1-LI 肝内神经的密度以及 NRG-1 与 VIP 的共定位程度。这些观察结果表明,位于肝内神经的 NRG-1 可能在 BPA 影响下与肝损伤和/或再生相关的过程中发挥作用。已经观察到高剂量的 BPA 会增加 NRG-1-LI 肝内神经的密度以及 NRG-1 与 VIP 的共定位程度。这些观察结果表明,位于肝内神经的 NRG-1 可能在 BPA 影响下与肝损伤和/或再生相关的过程中发挥作用。
更新日期:2020-06-05
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