Group A rotavirus (RVA) rarely causes severe complications such as encephalitis/encephalopathy. However, the pathophysiology of this specific complication remains unclear. Next‐generation sequence analysis was used to compare the entire genome sequences of RVAs detected in patients with encephalitis/encephalopathy and gastroenteritis. This study enrolled eight patients with RVA encephalitis/encephalopathy and 10 with RVA gastroenteritis who were treated between February 2013 and July 2014. Viral RNAs were extracted from patients' stool, and whole‐genome sequencing analysis was carried out to identify the specific gene mutations in RVA obtained from patients with severe neurological complications. Among the eight encephalitis/encephalopathy cases, six strains were DS‐1‐like G1P[8] and the remaining two were Wa‐like G1P[8] (G1‐P[8]‐I1‐R1‐C1‐M1‐A1‐N1‐T1‐E1‐H1). Meanwhile, eight of the 10 viruses detected in rotavirus gastroenteritis patients were DS‐1‐like G1P[8], and the remaining two were Wa‐like G1P[8]. These strains were further characterized by conducting phylogenetic analysis. No specific clustering was demonstrated in RVAs detected from encephalitis/encephalopathy patients. Although the DS‐1‐like G1P[8] strain was predominant in both groups, no specific molecular characteristics were detected in RVAs from patients with severe central nervous system complications.

中文翻译：

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从轮状病毒相关性脑炎/脑病患者获得的轮状病毒的分子特征。

A组轮状病毒（RVA）很少引起严重的并发症，例如脑炎/脑病。但是，这种特殊并发症的病理生理学仍不清楚。下一代序列分析用于比较在脑炎/脑病和胃肠炎患者中检测到的RVA的全基因组序列。这项研究招募了2013年2月至2014年7月间接受治疗的8例RVA脑炎/脑病患者和10例RVA肠胃炎患者。从患者粪便中提取病毒RNA，并进行了全基因组测序分析，以鉴定特定人群中的特定基因突变。从严重神经系统并发症患者获得RVA。在八例脑炎/脑病患者中，六个菌株为DS-1样G1P [8]，其余两个为Wa样G1P [8]（G1-P [8] -I1-R1-C1-M1-A1-N1-T1-E1-H1） 。同时，在轮状病毒肠胃炎患者中检测到的10种病毒中有8种是DS-1样G1P [8]，其余2种是Wa样G1P [8]。通过进行系统进化分析进一步表征了这些菌株。在脑炎/脑病患者中检测到的RVA中未显示出特定的聚类。尽管两组中都以DS-1类G1P [8]菌株为主，但在重度中枢神经系统并发症患者的RVA中未检测到特定的分子特征。通过进行系统进化分析进一步表征了这些菌株。在从脑炎/脑病患者中检测到的RVA中未发现特异性聚集。尽管两组都以DS-1样G1P [8]菌株为主，但在重度中枢神经系统并发症患者的RVA中未检测到特定的分子特征。通过进行系统进化分析进一步表征了这些菌株。在脑炎/脑病患者中检测到的RVA中未显示出特定的聚类。尽管两组中都以DS-1类G1P [8]菌株为主，但在重度中枢神经系统并发症患者的RVA中未检测到特定的分子特征。