Advances in Bacterial Biofilm Management for Maintaining Microbiome Homeostasis.,Biotechnology Journal

当前位置： X-MOL 学术 › Biotechnol. J. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Advances in Bacterial Biofilm Management for Maintaining Microbiome Homeostasis.
Biotechnology Journal ( IF 3.2 ) Pub Date : 2020-06-08 , DOI: 10.1002/biot.201900320
Zhao Liu ₁ , Can-Jian Hong ₁ , Yongshuai Yang ₁ , Lei Dai ₂ , Chun Loong Ho ₁

Affiliation

Certain microbial biofilm in the human‐microbiota community can negatively impact the host microbiome. This gives rise to various methods to prevent the formation of biofilms or to facilitate biofilm dispersal from surfaces and tissues in the host. Despite all these efforts, these persistent microbial biofilms on surfaces and in the host tissue can result in health problems to the host and its microbiome. It is the adaptive behavior of microbes within the biofilm that confers on these tenacious microbes the resistance to harsh environments, antibiotic treatments, and the ability to evade the host immune system. In this review, the approaches to combat microbial biofilm in the last decade are discussed. The biochemical pathway regulating biofilm formation is first discussed, followed by the discussion of the three approaches to combat biofilm formation: physical, chemical, and biological approaches. The advances in these approaches have given rise to methods of effectively dispersing the microbial biofilm and preventing the adherence of these microbial communities altogether. As there are numerous approaches to target biofilm, in this review the attempt is to provide insights on how these approaches have been used to modulate the host‐microbiome by looking at the individual strengths and weaknesses.

中文翻译：

维持微生物组稳态的细菌生物膜管理研究进展。

人类微生物群落中的某些微生物生物膜会对宿主微生物组产生负面影响。这产生了多种方法来防止生物膜的形成或促进生物膜从宿主表面和组织中的扩散。尽管进行了所有这些努力，但表面和宿主组织中的这些持久性微生物生物膜仍可能对宿主及其微生物组造成健康问题。正是生物膜内微生物的适应性行为赋予了这些顽强的微生物抵抗恶劣环境，抗生素治疗以及逃避宿主免疫系统的能力。在这篇综述中，讨论了近十年来对抗微生物生物膜的方法。首先讨论调节生物膜形成的生化途径，随后讨论了三种对抗生物膜形成的方法：物理，化学和生物方法。这些方法的进步产生了有效分散微生物生物膜并完全阻止这些微生物群落粘附的方法。由于靶向生物膜的方法很多，因此在本综述中，我们试图通过查看各个优缺点来提供有关这些方法如何用于调节宿主微生物组的见解。

更新日期：2020-06-08

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11