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Surface Modification of Luminescent LnIII Fluoride Core-Shell Nanoparticles with Acetylsalicylic acid (Aspirin): Synthesis, Spectroscopic and in Vitro Hemocompatibility Studies.
ChemMedChem ( IF 3.6 ) Pub Date : 2020-06-08 , DOI: 10.1002/cmdc.202000269
Dorota Kwiatek 1, 2 , Lucyna Mrówczyńska 3 , Natalia Stopikowska 1 , Marcin Runowski 1 , Andrzej Lesicki 3 , Stefan Lis 1
Affiliation  

Luminescent lanthanide fluoride core–shell (LaF3:Tb3+,Ce3+@SiO2‐NH2) nanoparticles, with acetylsalicylic acid (aspirin) coated on the surface have been obtained. The synthesized products, which combine the potential located in the silica shell with the luminescent activity of the core, were characterized in detail with the use of luminescence spectroscopy, Fourier transform infrared spectroscopy (FTIR), X‐ray diffraction (XRD), and transmission electron microscopy (TEM) methods. The in vitro effects of the modified luminescent nanoparticles on human red blood cell (RBC) membrane permeability, RBC shape, and sedimentation rate were investigated to assess the hemocompatibility of the obtained compounds. This study demonstrates that LaF3: Tb3+ 5 %, Ce3+ 10 %@SiO2‐NH2 nanoparticles with acetylsalicylic acid (aspirin) coated on the surface are very good precursors for multifunctional drug‐delivery systems or bio‐imaging probes that can be used safely in potential biomedical applications.

中文翻译:

乙酰水杨酸(阿司匹林)对LnIII氟化物荧光核壳纳米粒子的表面修饰:合成,光谱和体外血液相容性研究。

获得了表面涂有乙酰水杨酸(阿司匹林)的发光镧系氟化物核壳(LaF 3:Tb 3+,Ce 3+ @SiO 2 -NH 2)纳米粒子。通过使用发光光谱,傅立叶变换红外光谱(FTIR),X射线衍射(XRD)和透射光谱,对合成产物进行了详细表征,该产物将位于二氧化硅壳中的电势与核的发光活性相结合。电子显微镜(TEM)方法。在体外研究了修饰的发光纳米粒子对人红细胞(RBC)膜通透性,RBC形状和沉降速率的影响,以评估所得化合物的血液相容性。这项研究表明,在表面涂有乙酰水杨酸(阿司匹林)的LaF 3:Tb 3+ 5%,Ce 3+ 10%@ SiO 2 -NH 2纳米颗粒是多功能药物递送系统或生物成像探针的非常好的前体可以安全地用于潜在的生物医学应用中。
更新日期:2020-08-05
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