Exploring the Chemoselectivity towards Cysteine Arylation by Cyclometallated AuIII Compounds: New Mechanistic Insights.,ChemBioChem

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Exploring the Chemoselectivity towards Cysteine Arylation by Cyclometallated AuIII Compounds: New Mechanistic Insights.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-06-08 , DOI: 10.1002/cbic.202000262
Sophie R Thomas ₁ , Riccardo Bonsignore ₁ , Jorge Sánchez Escudero ₁ , Samuel M Meier-Menches ₂ , Christopher M Brown ₃ , Michael O Wolf ₃ , Giampaolo Barone ₄ , Louis Y P Luk ₁ , Angela Casini ₅

Affiliation

Getting your gold right: Cyclometallated Au^III complexes with bidentate C^N‐donor ligands enable chemoselective cysteine modification of peptides by C−S bond‐forming reductive elimination. By using combined high‐resolution mass spectrometry and QM/MM studies, further understanding of the mechanisms of Au^III‐templated cross‐coupling leading to cysteine arylation was achieved; this is essential to design selective gold compounds for bio‐orthogonal reactions.

中文翻译：

探索环金属化 AuIII 化合物对半胱氨酸芳基化的化学选择性：新的机理见解。

正确使用金：环金属化 Au ^III配合物与二齿 C^N 供体配体能够通过 C−S 键形成还原消除对肽进行化学选择性半胱氨酸修饰。通过结合高分辨率质谱和 QM/MM 研究，进一步了解了 Au ^III模板交叉偶联导致半胱氨酸芳基化的机制；这对于设计用于生物正交反应的选择性金化合物至关重要。

更新日期：2020-06-08

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