We report haplotype‐based GWASs for 33 blood parameters measured in 843 Italian Large White pigs. In the single‐trait analysis, a total of 30 QTL for number of basophils, six erythrocyte traits (haemoglobin, haematocrit, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, mean corpuscular volume and red blood cell count) and two clinical–biochemical traits (alkaline phosphatase and Ca²⁺ contents) were identified. In the multiple‐trait analysis, a total of five QTL affected three different clusters of traits. Only four of these QTL were already reported in the single‐marker and multi‐marker GWASs we previously carried out on the same pig population. QTL on SSC11 and SSC17 showed effects on multiple traits. These results further dissected the genetic architecture of parameters that could be used as proxies in breeding programmes for more complex traits. In addition, these results might help to better define the pig as an animal model for several blood‐related biological functions.

中文翻译：

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基于单体型的全基因组关联研究揭示了大型白猪血液学和临床生化参数的新基因座。

我们报告了基于单倍型的GWAS，对843头意大利大白猪的33种血液参数进行了测量。在单性状分析中，总共有30个QTL用于嗜碱性粒细胞的数量，六个红细胞性状（血红蛋白，血细胞比容，平均红细胞血红蛋白，平均红细胞血红蛋白浓度，平均红细胞体积和红细胞计数）和两个临床生化特征（碱性磷酸酶和Ca ²⁺内容）。在多性状分析中，共有五个QTL影响了三个不同的性状群。我们先前在同一猪群上进行的单标记和多标记GWAS中仅报告了四个QTL。SSC11和SSC17上的QTL对多种性状有影响。这些结果进一步剖析了可以用作育种程序中更复杂特征的代理参数的遗传结构。此外，这些结果可能有助于更好地将猪定义为具有多种血液相关生物学功能的动物模型。