当前位置: X-MOL 学术Adv. Healthcare Mater. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Additive Manufacturing of a Point-of-Care "Polypill:" Fabrication of Concept Capsules of Complex Geometry with Bespoke Release against Cardiovascular Disease.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-06-08 , DOI: 10.1002/adhm.202000236
Beatriz C Pereira 1 , Abdullah Isreb 1 , Mohammad Isreb 2 , Robert T Forbes 1 , Enoche F Oga 1 , Mohamed A Alhnan 3
Affiliation  

Polypharmacy is often needed for the management of cardiovascular diseases and is associated with poor adherence to treatment. Hence, highly flexible and adaptable systems are in high demand to accommodate complex therapeutic regimens. A novel design approach is employed to fabricate highly modular 3D printed “polypill” capsules with bespoke release patterns for multiple drugs. Complex structures are devised using combined fused deposition modeling 3D printing aligned with hot‐filling syringes. Two unibody highly modular capsule skeletons with four separate compartments are devised: i) concentric format: two external compartments for early release while two inner compartments for delayed release, or ii) parallel format: where nondissolving capsule shells with free‐pass corridors and dissolution rate‐limiting pores are used to achieve immediate and extended drug releases, respectively. Controlling drug release is achieved through digital manipulation of shell thickness in the concentric format or the size of the rate limiting pores in the parallel format. Target drug release profiles are achieved with variable orders and configurations, hence confirming the modular nature with capacity to accommodate therapeutics of different properties. Projection of the pharmacokinetic profile of this digital system capsules reveal how the developed approach can be applied in dose individualization and achieving multiple desired pharmacokinetic profiles.

中文翻译:

即时医疗点“ Polypill”的增材制造:具有复杂形状的定制概念胶囊,可量身定制,以对抗心血管疾病。

多元药物通常是治疗心血管疾病所需的药物,并且与依从性差有关。因此,迫切需要高度灵活和适应性强的系统以适应复杂的治疗方案。采用一种新颖的设计方法来制造具有多种药物定制释放模式的高度模块化3D打印“ polypill”胶囊。使用结合热填充注射器的3D打印组合熔合沉积模型设计出复杂的结构。设计了两个具有四个独立隔室的一体式高度模块化胶囊骨架:i)同心形式:两个外部隔室用于早期释放,而两个内部隔室用于延迟释放,或者ii)平行形式:使用具有自由通过通道和限制溶出速度的孔的非溶性胶囊壳分别实现立即和延长的药物释放。通过对同心形式的壳厚度或平行形式的限速孔大小进行数字控制,可以控制药物的释放。目标药物释放曲线以可变的顺序和配置实现,因此确认了模块化性质以及适应不同性质治疗剂的能力。该数字系统胶囊的药代动力学特征的投影揭示了如何将开发的方法应用于剂量个体化和实现多种所需的药代动力学特征。通过对同心形式的壳厚度或平行形式的限速孔大小进行数字控制,可以控制药物的释放。目标药物释放曲线以可变的顺序和配置实现,因此确认了模块化性质以及适应不同性质治疗剂的能力。该数字系统胶囊的药代动力学特征的投影揭示了如何将开发的方法应用于剂量个体化和实现多种所需的药代动力学特征。通过对同心形式的壳厚度或平行形式的限速孔大小进行数字控制,可以控制药物的释放。目标药物释放曲线以可变的顺序和配置实现,因此确认了模块化性质以及适应不同性质治疗剂的能力。该数字系统胶囊的药代动力学特征的投影揭示了如何将开发的方法应用于剂量个体化和实现多种所需的药代动力学特征。
更新日期:2020-07-08
down
wechat
bug