Phytochemical studies on Momordica foetida led to the isolation and characterization of Momordin (23,24,25,26,27-pentanorcucurbitacin) (3), a new pentanor cucurbitane along with the known β-sitosterol 3-O-β-D-glucopyranoside (4), β-sitosterol (5) and kaempferol-7-O-ß-D-glucopyranoside (6). In adition to those components, two previously unreported cucurbitane glucosides, namely 3β-hydroxy-7-oxo-23(R)-cucurbita-5,24-diene-23-O-β-D-glucopyranoside (Momordiside A) (1) and 3β-hydroxy-7β-methoxy-23(R)-cucurbita-5,24-diene-23-O-β-D-glucopyranoside (Momordiside B) (2) were also obtained. The structures were elucidated by HR-ESI-MS and spectroscopic analysis including 1D- and 2D-NMR. Compounds 1 and 2 showed significant antioxidant potential in DPPH radical scavenging assay. In addition, compound 2 further revealed significant inhibitory potential against the enzyme urease in vitro as well as moderate activity against oral cancer cell line CAL-27.

对Momordica foetida的植物化学研究导致了Momordin（23,24,25,26,27-pentanorcucurbitacin）（3）的分离和鉴定，这是一种新的五角葫芦烷以及已知的β-谷甾醇3- O - β -D-吡喃葡萄糖苷（4），β-谷甾醇（5）和山奈酚7 -O-ß -D-吡喃葡萄糖苷（6）。在ADITION那些部件，两个先前未报告的葫芦糖苷，即3 β羟基-7-氧代- 23（- [R）-cucurbita-5,24 -二烯-23- ø - β -D-吡喃葡糖苷（Momordiside A）（1）和3β-羟基-7β还获得了-甲氧基-23（R）-葫芦巴-5，24-二烯-23- O - β -D-吡喃葡萄糖苷（Momordiside B）（2）。通过HR-ESI-MS和包括1D-NMR和2D-NMR的光谱分析阐明了结构。化合物1和2在DPPH自由基清除试验中显示出显着的抗氧化剂潜力。另外，化合物2进一步显示出在体外对脲酶的显着抑制潜力以及对口腔癌细胞系CAL-27的中等活性。