CD8+ T cells are crucial for immunity against viral infections, including HIV. Several characteristics of CD8+ T cells, such as polyfunctionality and cytotoxicity, have been correlated with effective control of HIV. However, most of these correlates have been established in the peripheral blood. Meanwhile, HIV primarily replicates in lymphoid tissues. Therefore, it is unclear which aspects of CD8+ T cell biology are shared and which are different between blood and lymphoid tissues in the context of HIV infection. In this review, we will recapitulate the latest advancements of our knowledge on lymphoid tissue CD8+ T cells during HIV infection and discuss the insights these advancements might provide for the development of a HIV cure.

CD8+ T 细胞对于抵抗病毒感染（包括 HIV）的免疫力至关重要。 CD8+ T 细胞的多种特性，例如多功能性和细胞毒性，与有效控制 HIV 相关。然而，大多数这些相关性已在外周血中建立。与此同时，艾滋病毒主要在淋巴组织中复制。因此，尚不清楚在 HIV 感染的情况下，血液和淋巴组织的 CD8+ T 细胞生物学的哪些方面是相同的，哪些方面是不同的。在这篇综述中，我们将概述 HIV 感染期间淋巴组织 CD8+ T 细胞知识的最新进展，并讨论这些进展可能为 HIV 治疗方法的开发提供的见解。