For the diagnosis of anti-MAG polyneuropathy the commercial ELISA manufacturer currently recommends a cut-off of 1000 Bühlmann Titer Units (BTU). We analyzed sera from 80 anti-MAG neuropathy patients and 383 controls (with other neuropathies or healthy controls) to assess the ELISA sensitivity and specificity at different thresholds. A better combination of sensitivity/specificity was found at a threshold >1500 BTU than at >1000 BTU. The best value of specificity was obtained at threshold >7000 BTU. There was a diagnostic grey area between 1500 and 7000 BTU in which the clinical phenotypes as well as electrophysiological studies need to be carefully assessed particularly to differentiate CIDP and anti-MAG neuropathy.

中文翻译：

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用于神经病患者抗 MAG 抗体的商业 ELISA 检测的敏感性和特异性

对于抗 MAG 多发性神经病的诊断，商业 ELISA 制造商目前建议临界值为 1000 Bühlmann Titer Units (BTU)。我们分析了 80 名抗 MAG 神经病患者和 383 名对照（与其他神经病或健康对照）的血清，以评估不同阈值下的 ELISA 敏感性和特异性。在阈值 >1500 BTU 时比在 >1000 BTU 时发现了更好的敏感性/特异性组合。在阈值 >7000 BTU 时获得最佳特异性值。在 1500 到 7000 BTU 之间存在诊断灰色区域，需要仔细评估临床表型和电生理学研究，特别是要区分 CIDP 和抗 MAG 神经病变。