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An efficient and inexpensive method for functionalizing metallic biomaterials used in orthopedic applications
Colloid and Interface Science Communications ( IF 4.7 ) Pub Date : 2020-06-08 , DOI: 10.1016/j.colcom.2020.100282
Soria Hamdaoui , Ambroise Lambert , Hafit Khireddine , Rémy Agniel , Annelise Cousture , Régis Coulon , Olivier Gallet , Séverine Alfonsi , Mathilde Hindié

Implantations of metallic biomaterials are being carried out more and more frequently due to accident and population aging. Therefore, there is a need for new metallic implants which can combine properties such as durability, biocompatibility and affordability. In this study, multilayer functionalized 316 L stainless steel (SS) supports resistant to steam sterilization were presented. An electropolymerization of pyrrole was performed on SS supports to obtain a protective layer. This polypyrrole coating rendered SS surface resistant to corrosion. Then an electrodeposition of Calcium Phosphate (CaP) doped with increasing concentrations of silicon (Si) ranging from 0 to 2 mM was tested to improve support bone integration. The impacts of silicon addition in the CaP coating without or after steam sterilization were analyzed by profilometry, Scanning Electron Microscopy and Fourier Transform Infrared Spectroscopy. These latter revealed that CaP doped with 0.5 mM of Si constituted the optimal support formulation, presenting sterilization resistance and good biocompatibility.



中文翻译:

一种用于骨科应用的金属生物材料功能化的高效且廉价的方法

由于事故和人口老龄化,金属生物材料的植入越来越频繁。因此,需要可以结合诸如耐久性,生物相容性和可负担性的性质的新型金属植入物。在这项研究中,提出了耐蒸汽灭菌的多层功能化316 L不锈钢(SS)支架。在SS载体上进行吡咯的电聚合以获得保护层。这种聚吡咯涂层使SS表面具有抗腐蚀能力。然后,对电沉积磷酸钙(CaP)进行电沉积,掺杂浓度范围从0到2 mM的不断增加的硅(Si),以改善支撑骨的整合度。通过轮廓分析法分析了未经蒸汽灭菌或经过蒸汽灭菌后,CaP涂层中添加硅的影响,扫描电子显微镜和傅立叶变换红外光谱。后者表明,掺有0.5 mM Si的CaP构成了最佳的载体配方,具有杀菌性和良好的生物相容性。

更新日期:2020-06-08
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