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Circulating Th1/17 cells serve as a biomarker of disease severity and a target for early intervention in AChR-MG patients.
Clinical Immunology ( IF 4.5 ) Pub Date : 2020-06-08 , DOI: 10.1016/j.clim.2020.108492
Qian Ma 1 , Hao Ran 2 , Yingkai Li 1 , Yaru Lu 1 , Xiaoxi Liu 1 , Huan Huang 1 , Wenhao Yang 1 , Lu Yu 1 , Pei Chen 1 , Xin Huang 1 , Li Qiu 1 , Zhongqiang Lin 1 , Changyi Ou 1 , Weibin Liu 1
Affiliation  

Interleukin-17-expressing CD4+ T helper 17 (Th17) cells are considered to be critical regulators of thymic inflammation in AChR-MG patients. However, Th17 cells are functionally heterogeneous and circulating Th17 subsets are incompletely understood in AChR-MG patients. Here, we studied characteristics of Th17 subsets in peripheral blood from treatment-naïve AChR-MG patients, patients treated with immunosuppressants, as well as healthy controls. We found increased frequencies of circulating Th1-like Th17 (Th1/17) (IFN-γ + IL-17 + CD4 + CD3+) cells, which declined earlier than conventional Th17 (IFN-γ − IL-17 + CD4 + CD3+) cells in patients who respond well to immunosuppression treatment. Additionally, circulating Th1/17 cell frequencies were found to correlate positively with disease severity. Further, compared to conventional Th17 cells, Th1/17 cells showed an elevated expression of IFNG, TBX21, IL23R, CSF2, and a reduced expression of AHR and IL10. Taken together, our results suggest circulating Th1/17 cells may serve as a biomarker of disease severity and provide a strong rationale for early intervention in AChR-MG patients.



中文翻译:

循环中的Th1 / 17细胞是疾病严重程度的生物标志物,也是AChR-MG患者早期干预的目标。

表达白介素17的CD4 + T辅助细胞17(Th17)细胞被认为是AChR-MG患者胸腺炎症的关键调节剂。但是,Th17细胞在功能上是异质的,在AChR-MG患者中,循环中的Th17亚型还不完全清楚。在这里,我们研究了未经治疗的AChR-MG患者,接受免疫抑制剂治疗的患者以及健康对照组的外周血Th17亚型的特征。我们发现循环中的Th1类Th17(Th1 / 17)(IFN-γ+ IL-17 + CD4 + CD3 +)细胞的频率增加,其下降速度比传统Th17(IFN-γ-IL-17 + CD4 + CD3 +)细胞更早对免疫抑制治疗反应良好的患者。此外,发现循环中的Th1 / 17细胞频率与疾病严重程度呈正相关。此外,与传统的Th17细胞相比,IFNG,TBX21,IL23R,CSF2以及AHRIL10的表达降低。综上所述,我们的研究结果表明循环中的Th1 / 17细胞可能是疾病严重程度的生物标志,并为AChR-MG患者的早期干预提供了强有力的依据。

更新日期:2020-07-13
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