Affective disorders (depression and anxiety), psychosis, impulse control disorders, and apathy are common and sometimes disabling psychiatric conditions in Parkinson disease (PD). Psychiatric aspects of PD are associated with numerous adverse outcomes, yet in spite of this and their high frequency, there remains incomplete understanding of epidemiology, presentation, risk factors, neural substrate, and management strategies. Psychiatric features are typically co- or multimorbid, and there is great intra- and interindividual variability in presentation [1]. The neuropathophysiological changes that occur in PD, as well as the association between PD treatment and particular psychiatric disorders, suggest a neurobiological contribution to many psychiatric symptoms. There is evidence that psychiatric disorders in PD are still under-recognized and undertreated, and although psychotropic medication use is common, randomized controlled trials demonstrating efficacy and tolerability are largely lacking. Future research on neuropsychiatric complications in PD should be oriented toward determining modifiable correlates or risk factors, and most importantly, establishing efficacious and well-tolerated treatment strategies.

情感障碍（抑郁和焦虑）、精神病、冲动控制障碍和冷漠是帕金森病 (PD) 中常见的、有时甚至是致残的精神疾病。 PD 的精神方面与许多不良后果相关，但尽管这种情况及其发生频率很高，但对流行病学、表现、危险因素、神经基质和管理策略的了解仍然不完全。精神病学特征通常是共病或多病的，并且个体内和个体间的表现存在很大差异[1]。 PD 中发生的神经病理生理学变化，以及 PD 治疗与特定精神疾病之间的关联，表明神经生物学对许多精神症状有贡献。有证据表明，帕金森病中的精神疾病仍然未被充分认识和治疗，尽管精神药物的使用很常见，但很大程度上缺乏证明疗效和耐受性的随机对照试验。未来对帕金森病神经精神并发症的研究应着眼于确定可改变的相关因素或危险因素，最重要的是，建立有效且耐受性良好的治疗策略。