Sulfoxides are key scaffolds in the synthesis of pharmaceutically active molecules. A large number of sulfoxides are indispensable ingredients in the structure of most antibiotics, biological and natural products such as Modafinil, Adrafinil, CRL-40,941 or fladrafinil, Fipronil, Oxydemetonmethyl, Omeprazole, Pantoprazole, Lansoprazole and Rabeprazole. The oxidation of sulfides is the most common and efficient strategy for the preparation of sulfoxides. Recently, many protocols based on using transition metals have been reported for the oxidation of sulfides to the sulfoxides. In this paper, we summarized a nice category of the reported protocols in the literature for the oxidation of sulfides to sulfoxides.

亚砜是药物活性分子合成中的关键支架。在大多数抗生素，生物和天然产品（例如莫达非尼，阿德拉非尼，CRL-40,941或黄酮拉非尼，非诺酮，羟甲基苯乙酮，奥美拉唑，Pan托拉唑，兰索拉唑和雷贝拉唑）中，大量亚砜是必不可少的成分。硫化物的氧化是制备亚砜的最常见，最有效的策略。近来，已经报道了许多基于使用过渡金属的方案，用于将硫化物氧化成亚砜。在本文中，我们总结了文献中用于将硫化物氧化为亚砜的已报道方案的一个很好的类别。