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One-Pot, Regioselective Synthesis of Homopropargyl Alcohols using Propargyl Bromide and Carbonyl Compound by the Mg-mediated Reaction under Solvent-free Conditions
Letters in Organic Chemistry ( IF 0.7 ) Pub Date : 2020-05-31 , DOI: 10.2174/1570178616666190926104037 Xiaofang Ma 1 , Shunxi Li 2 , Samrat Devaramani 3 , Guohu Zhao 1 , Daqian Xu 1
中文翻译：
在无溶剂条件下通过Mg介导的反应，使用炔丙基溴和羰基化合物一锅法区域选择性合成高炔丙醇
更新日期：2020-05-31
Letters in Organic Chemistry ( IF 0.7 ) Pub Date : 2020-05-31 , DOI: 10.2174/1570178616666190926104037 Xiaofang Ma 1 , Shunxi Li 2 , Samrat Devaramani 3 , Guohu Zhao 1 , Daqian Xu 1
Affiliation
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The elimination of volatile organic solvents in organic synthesis is the most important goal in “Green” chemistry. We report a simple, efficient and facile method for the addition of progargyl bromide to carbonyl compounds using Mg metal as a mediator under solvent-free conditions which could regioselectively generate homopropargyl alcohols efficiently in good to excellent yields. The procedure has advantages such as short reaction time, operationally simple, excellent product yields, high regioselectivity and organic solvent-free.
中文翻译：
在无溶剂条件下通过Mg介导的反应，使用炔丙基溴和羰基化合物一锅法区域选择性合成高炔丙醇
在有机合成中消除挥发性有机溶剂是“绿色”化学中最重要的目标。我们报告了一种简单，有效且简便的方法，用于在无溶剂条件下使用Mg金属作为介体，将炔丙基溴添加到羰基化合物中，该方法可以区域选择性地高效生成高炔丙醇，且收率高至优异。该方法具有诸如反应时间短，操作简单，产物收率优异，区域选择性高和无有机溶剂的优点。
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