Letters in Organic Chemistry ( IF 0.7 ) Pub Date : 2020-05-31 , DOI: 10.2174/1570178617666191218104241 Nguyen Minh Chau 1 , Ha Manh Tuan 1 , Tran Manh Hung 2 , Nguyen Tien Dat 1 , Nguyen Hai Dang 3
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Eight secondary metabolites (1-8) were isolated from the roots of Vietnamese Eurycoma longifolia. The structures of these compounds were elucidated using a variety of spectroscopic methods. Among the compounds was eurylongilactone A (1), a new oxygenated C20 quassinoid with a 11β,20-epoxy bridge. The anti-inflammatory activities of the compounds were evaluated against LPSinduced NO production in RAW264.7 cells. Compound 1 and ethyl ferulate (8) had the strongest inhibitory effects, with IC50 values of 3.03 ± 0.73 and 3.56 ± 0.43 µM, respectively. Compounds 2, 4, and 7 had moderate activity.
中文翻译：
长叶杜仲根的消炎成分
从越南长叶Eurycoma longifolia的根中分离出8种次级代谢产物（1-8）。使用多种光谱方法阐明了这些化合物的结构。在这些化合物中，有eurylongilactone A（1），这是一种新的带有11β，20-环氧桥的氧化C20 quassinoid。评估化合物的抗炎活性，以抵抗LP26诱导的RAW264.7细胞中NO生成。化合物1和阿魏酸乙酯（8）具有最强的抑制作用，IC50值分别为3.03±0.73和3.56±0.43 µM。化合物2、4和7具有中等活性。
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