A simple and efficient method was developed for the synthesis of pyrazole derivatives via a one-pot reaction of 1,3-diketone and substituted hydrazines in the presence of nano-SnCl4/SiO2 as a mild catalyst. A series of some pyrazole derivatives (P1-P11) was synthesized and evaluated as antifungal and anti-cancer agents. Compounds P10 and P11 were demonstrated. The antimicrobial activities of the synthetic compounds showed that compounds P10 and P11 most excellently inhibited the growth of dermatophytes or Aspergillus species, respectively. Therefore, the cytotoxic activities of these compounds on two human cancer cell lines, A549 (lung cancer) and MCF-7 (breast cancer) were further assessed. Hence, results demonstrated that beside antifungal activity, P10 had also desirable cytotoxic effect on investigated cancerous cell lines, even higher than cisplatin.

开发了一种简单有效的方法，在纳米SnCl4 / SiO2作为温和催化剂的情况下，通过1,3-二酮与取代肼的一锅反应合成吡唑衍生物。合成了一些吡唑衍生物（P1-P11），并作为抗真菌和抗癌药进行了评估。证实了化合物P10和P11。合成化合物的抗菌活性表明，化合物P10和P11分别最能出色地抑制皮肤真菌或曲霉菌的生长。因此，进一步评估了这些化合物对两种人类癌细胞系A549（肺癌）和MCF-7（乳腺癌）的细胞毒活性。因此，结果表明，P10除了具有抗真菌活性外，还对研究的癌细胞系具有理想的细胞毒性作用，