Actually, many discussions on the potential risks of silver nanoparticles (AgNPs) have been reported; however, unfortunately, very few considered the great differences between the nature of silver and sources of their syntheses. All data suggested that the effects on toxicity of AgNPs are related to the combination of the specific properties of AgNPs. In this context, this review presents and discusses the recent progress in the nanotoxicity of AgNPs, obtained by different biogenic synthetic protocols, in comparison with chemical synthetic methods, driving to the formation of nanoparticles with diverse structures, and size distributions. Biogenic syntheses of AgNPs using several biological sources and other chemical agents are presented and discussed. Toxicity in different animals is also presented and discussed. By considering the actual state of the art, it can be assumed that oral, intravenous and inhalation doses of AgNPs from 0.1 to 2 mg/Kg in mice and rats are considered a safe administration. In terms of ecotoxicity, it is more concerning since many of the in vivo assays showed a very low lethal dose, i.e., 50% (LD50). Therefore, we have to be very careful with the AgNPs residues in the environment.

实际上，已经报道了许多有关银纳米颗粒（AgNPs）潜在风险的讨论；然而，不幸的是，很少有人考虑到银的性质与其合成来源之间的巨大差异。所有数据表明，对AgNPs毒性的影响与AgNPs特定特性的组合有关。在这种情况下，本综述介绍并讨论了通过化学合成方法，通过不同的生物合成方法获得的AgNPs纳米毒性的最新进展，并推动了具有不同结构和尺寸分布的纳米颗粒的形成。提出并讨论了使用几种生物来源和其他化学试剂的AgNPs的生物合成。还介绍和讨论了对不同动物的毒性。通过考虑现有技术的实际状况，可以认为在小鼠和大鼠中口服，静脉内和吸入剂量的AgNPs从0.1到2 mg / Kg被认为是安全的。在生态毒性方面，这是更令人担忧的，因为许多体内试验显示出非常低的致死剂量，即50％（LD50）。因此，我们必须非常小心环境中的AgNPs残留。