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Higher Odds of Type 2 Diabetes for Some Blood Groups
Public Health Genomics ( IF 1.3 ) Pub Date : 2020-01-01 , DOI: 10.1159/000506294
Jafar Navabi 1 , Seyed Mohammad Navabi 2 , Niloufar Hemmati 1 , Zahra Shaahmadi 1 , Abbas Aghaei 3
Affiliation  

Background: Diabetes is one of the most common metabolic diseases in humans that cause disruption in glucose and fat metabolism. The determination of the ABO blood group system is hereditary and both diabetes and blood groups have a genetic basis. Objectives: The aim of this study was to investigate the odds of type 2 diabetes for some blood groups. Methods: This case-control study was conducted in hospitals of Kermanshah in 2018. The case group consisted of patients with diabetes admitted to hospital and the control group of nondiabetic patients hospitalized in the surgical ward. Information such as age, sex, BMI, family history of diabetes and blood group is collected and analyzed by the univariate and multivariate logistic regression method. Results: A total of 750 patients were enrolled in this study. The number of participants in both groups was 375. The average ages of the participants were 50.51 and 51.62 years, respectively. 67.5% of the patients in the case group were female in comparison with 73.6% of those in the control group. The value of Rh+ in the case and control groups was 94.4 and 93.6%, respectively (p = 0.645). The chance of having diabetes for patients with blood group A was 76% higher than for those with blood group O (p = 0.006). Conclusion: According to the results of this study, the odds of type 2 diabetes for people in blood group A was higher than for those in other blood groups. It is recommended that blood group A be considered as a risk factor in the screening of type 2 diabetes.

中文翻译:

某些血型患 2 型糖尿病的几率更高

背景:糖尿病是人类最常见的代谢疾病之一,会导致葡萄糖和脂肪代谢紊乱。ABO血型系统的确定是遗传的,糖尿病和血型都有遗传基础。目的:本研究的目的是调查某些血型患 2 型糖尿病的几率。方法:本病例对照研究于2018年在克尔曼沙阿医院进行,病例组由住院的糖尿病患者和手术病房住院的非糖尿病患者组成。通过单变量和多变量逻辑回归方法收集和分析年龄、性别、BMI、糖尿病家族史和血型等信息。结果:本研究共纳入 750 名患者。两组参与者人数均为375人。参与者的平均年龄分别为50.51和51.62岁。病例组 67.5% 的患者为女性,而对照组为 73.6%。病例组和对照组的 Rh+ 值分别为 94.4% 和 93.6% (p = 0.645)。A 型血患者患糖尿病的几率比 O 型血患者高 76%(p = 0.006)。结论:根据这项研究的结果,A 型血的人患 2 型糖尿病的几率高于其他血型的人。建议将 A 型血作为 2 型糖尿病筛查的危险因素。病例组中有 5% 的患者为女性,而对照组为 73.6%。病例组和对照组的 Rh+ 值分别为 94.4% 和 93.6% (p = 0.645)。A 型血患者患糖尿病的几率比 O 型血患者高 76%(p = 0.006)。结论:根据这项研究的结果,A 型血的人患 2 型糖尿病的几率高于其他血型的人。建议将 A 型血作为 2 型糖尿病筛查的危险因素。病例组中有 5% 的患者为女性,而对照组为 73.6%。病例组和对照组的 Rh+ 值分别为 94.4% 和 93.6% (p = 0.645)。A 型血患者患糖尿病的几率比 O 型血患者高 76%(p = 0.006)。结论:根据这项研究的结果,A 型血的人患 2 型糖尿病的几率高于其他血型的人。建议将 A 型血作为 2 型糖尿病筛查的危险因素。结论:根据这项研究的结果,A 型血的人患 2 型糖尿病的几率高于其他血型的人。建议将 A 型血作为 2 型糖尿病筛查的危险因素。结论:根据这项研究的结果,A 型血的人患 2 型糖尿病的几率高于其他血型的人。建议将 A 型血作为 2 型糖尿病筛查的危险因素。
更新日期:2020-01-01
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