Background: Diabetic retinopathy is characterised by morphological lesions in the retina secondary to disturbances in retinal blood flow. Previous studies have shown that the carbonic anhydrase inhibitor (CAI) dorzolamide can induce immediate dilatation of retinal arterioles and a sustained increase in retinal blood flow in primary open-angle glaucoma. However, the effect of sustained treatment with CAI on retinal arterioles in normal persons and in patients with diabetic retinopathy is unknown. Methods: The Dynamic Vessel Analyzer was used to assess the baseline diameter and the diameter response of retinal arterioles during an increase in arterial blood pressure induced by isometric exercise and during flicker stimulation before and 2 h, 24 h and 1 week after onset of topical treatment with dorzolamide. At each examination the diameter responses were studied before and during breathing in of a hypercapnic gas mixture. Results: Treatment with dorzolamide for 1 week significantly increased the diameter of retinal arterioles in normal persons, and breathing in of a hypercapnic gas mixture reduced this response. The pathological vasodilatation and reduced retinal autoregulation in patients with diabetic retinopathy were unaffected by dorzolamide and hypercapnia. Conclusions: The study suggests a lack of relevance of CAI for the treatment of pathological vasodilatation in early diabetic retinopathy.
Kompass Ophthalmol 2020;6:83-84

中文翻译：

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第1型糖尿病在Netzhaut von Patienten的CO2-abhängigenGefäß调节

背景：糖尿病性视网膜病的特征是继发于视网膜血流障碍的视网膜形态学损害。先前的研究表明，碳酸酐酶抑制剂（CAI）多佐胺可以诱导视网膜小动脉立即扩张，并在原发性开角型青光眼中持续增加视网膜血流量。然而，对于正常人和患有糖尿病性视网膜病的患者，用CAI持续治疗对视网膜小动脉的作用尚不清楚。方法：动态血管分析仪用于评估等距运动诱发的动脉血压升高过程中以及多佐胺类药物局部治疗开始前，治疗后2小时，24小时和1周期间的基线直径和视网膜小动脉的直径响应。在每次检查中，在吸入高碳酸气体混合物之前和期间研究直径响应。结果：多佐胺治疗1周可显着增加正常人的视网膜小动脉直径，而吸入高碳酸气体混合物则可降低这种反应。糖尿病性视网膜病患者的病理血管舒张和视网膜自体调节降低不受多佐胺和高碳酸血症的影响。结论：研究表明，在早期糖尿病性视网膜病变中，CAI与病理性血管舒张的治疗缺乏相关性。
Kompass Ophthalmol 2020; 6：83-84