当前位置: X-MOL 学术J. Innate Immun. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Humoral First-Line Mucosal Innate Defence in vivo.
Journal of Innate Immunity ( IF 4.7 ) Pub Date : 2020-03-23 , DOI: 10.1159/000506515
Carl Persson 1
Affiliation  

Based on observations in vivo in guinea-pig and human airways, this review presents plasma exudation as non-sieved transmission of bulk plasma across an unperturbed mucosa that maintains its normal barrier functions. Several steps have led to the present understanding of plasma exudation as a non-injurious response to mucosal challenges. The implication of a swift appearance of all circulating multipotent protein systems (also including antimicrobial peptides that now are viewed as being exclusively produced by local cells) on challenged, but intact, mucosal surfaces cannot be trivial. Yet, involvement of early plasma exudation responses in innate mucosal immunology has dwelled below the radar. Admittedly, exploration of physiological plasma exudation mechanisms requires in vivo approaches beyond mouse studies. Plasma exudation also lacks the specificity that is a hallmark of biological revelations. These aspects separate plasma exudation from mainstream progress in immunology. The whole idea, presented here, thus competes with strong paradigms currently entertained in the accepted research front. The present focus on humoral innate immunity in vivo further deviates from most discussions, which concern cell-mediated innate defence. Indeed, plasma exudation has emerged as sole in vivo source of major mucosal defence proteins that now are viewed as local cell produce. In conclusion, this review highlights opportunities for complex actions and interactions provided by non-sieved plasma proteins/peptides on the surface of intact mucosal barriers in vivo.
J Innate Immun


中文翻译:

体内体液一线粘膜固有防御。

基于在豚鼠和人类气道中的体内观察结果,本综述将血浆渗出表示为未过滤的散装血浆通过保持其正常屏障功能的未扰动粘膜的传输。几个步骤已导致目前对血浆渗出的了解是对粘膜挑战的非伤害性反应。所有循环的多能蛋白质系统(也包括现在被认为是局部细胞唯一产生的抗菌肽)迅速出现在受攻击但完整的粘膜表面上的意义不小。然而,早期血浆渗出反应参与先天性粘膜免疫学的研究已远远低于雷达。诚然,对生理血浆渗出机制的探索需要超越小鼠研究的体内方法。血浆渗出也缺乏作为生物揭示的特征的特异性。这些方面使血浆渗出与免疫学的主流进展分开。因此,这里提出的整个想法与目前在公认的研究前沿所接受的强大范式竞争。目前对体内体液先天免疫的关注进一步偏离了大多数讨论,后者涉及细胞介导的先天防御。实际上,血浆渗出已成为主要粘膜防御蛋白的唯一体内来源,现在被认为是局部细胞产生。总而言之,本综述着重介绍了完整的黏膜屏障表面上未过筛分的血浆蛋白/肽所提供的复杂作用和相互作用的机会。这些方面使血浆渗出与免疫学的主流进展分开。因此,这里提出的整个想法与目前在公认的研究前沿所接受的强大范式竞争。目前对体内体液先天免疫的关注进一步偏离了大多数讨论,后者涉及细胞介导的先天防御。确实,血浆渗出已成为主要粘膜防御蛋白的唯一体内来源,现在被认为是局部细胞产生。总而言之,本综述着重介绍了完整的黏膜屏障表面上未过筛分的血浆蛋白/肽所提供的复杂作用和相互作用的机会。这些方面使血浆渗出与免疫学的主流进展分开。因此,这里提出的整个想法与目前在公认的研究前沿所接受的强大范式竞争。目前对体内体液先天免疫的关注进一步偏离了大多数讨论,后者涉及细胞介导的先天防御。实际上,血浆渗出已成为主要粘膜防御蛋白的唯一体内来源,现在被认为是局部细胞产生。总之,本综述着重指出了完整的粘膜屏障表面上未过筛分的血浆蛋白/肽所提供的复杂作用和相互作用的机会。目前对体内体液先天免疫的关注进一步偏离了大多数讨论,后者涉及细胞介导的先天防御。实际上,血浆渗出已成为主要粘膜防御蛋白的唯一体内来源,现在被认为是局部细胞产生。总而言之,本综述着重介绍了完整的黏膜屏障表面上未过筛分的血浆蛋白/肽所提供的复杂作用和相互作用的机会。目前对体内体液先天免疫的关注进一步偏离了大多数讨论,后者涉及细胞介导的先天防御。确实,血浆渗出已成为主要粘膜防御蛋白的唯一体内来源,现在被认为是局部细胞产生。总而言之,本综述着重介绍了完整的黏膜屏障表面上未过筛分的血浆蛋白/肽所提供的复杂作用和相互作用的机会。
免疫学杂志
更新日期:2020-03-23
down
wechat
bug