Background: Diabetes as a metabolic disorder can affect the various systems of the body, resulting in a decrease in cardiovascular fitness, sleep quality, and life quality that can lead to depression and fatigue. Aim: We analyzed cardiovascular fitness, sleep quality, depression, fatigue, and quality of life among individuals with a glycated hemoglobin (HBA1C) level >6.5% and ≤6.5%, as well as the relationship among glycated hemoglobin, maximal oxygen consumption (VO2max), obesity, sleep quality, depression, and duration of diabetes. Method: HBA1C (mean: 5.90 ± 0.93%) was studied in a total of 70 subjects (mean age: 62.37 ± 7.5 years). The 2 study groups were as follows: group A, HBA1C >6.5%, and group B, HBA1C ≤6.5%. BMI, VO2max, quality of sleep and life, depression, and fatigue were assessed in both groups. Results: There was a statistically significant difference between the groups at a significance level of p < 0.001. Group A had a lower cardiovascular fitness, a poor sleep quality, and increased depression compared to group B. A statistically significant negative linear correlation was found between VO2max and glycated hemoglobin, and a significant positive linear correlation was found between glycated hemoglobin and duration of diabetes, poor quality of sleep, and depression for all subjects, which was insignificant in the groups. Conclusions: A long duration of diabetes and an increased glycemic status may influence cardiovascular fitness, sleep quality, and life quality, leading to depression and fatigue.

中文翻译：

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2 型糖尿病患者的心血管健康、睡眠质量、抑郁、疲劳和生活质量与糖化血红蛋白水平相关的分析

背景：糖尿病作为一种代谢紊乱会影响身体的各个系统，导致心血管健康、睡眠质量和生活质量下降，从而导致抑郁和疲劳。目的：我们分析了糖化血红蛋白 (HBA1C) 水平 >6.5% 和≤6.5% 的个体的心血管健康、睡眠质量、抑郁、疲劳和生活质量，以及糖化血红蛋白与最大耗氧量（VO2max）之间的关系)、肥胖、睡眠质量、抑郁和糖尿病病程。方法：在总共 70 名受试者（平均年龄：62.37 ± 7.5 岁）中研究了 HBA1C（平均：5.90 ± 0.93%）。2个研究组如下：A组，HBA1C>6.5%，B组，HBA1C≤6.5%。评估两组的 BMI、VO2max、睡眠和生活质量、抑郁和疲劳。结果：在p < 0.001 的显着性水平上，各组之间存在统计学上的显着差异。与 B 组相比，A 组心血管健康状况较差，睡眠质量较差，抑郁症增加。 VO2max 与糖化血红蛋白呈显着负线性相关，糖化血红蛋白与糖尿病病程呈显着正线性相关、睡眠质量差和所有受试者的抑郁，这在各组中不显着。结论：长期的糖尿病病程和升高的血糖状态可能会影响心血管健康、睡眠质量和生活质量，导致抑郁和疲劳。与 B 组相比，睡眠质量差，抑郁增加。 VO2max 与糖化血红蛋白呈显着负线性相关，糖化血红蛋白与糖尿病病程、睡眠质量差和抑郁呈显着正线性相关对于所有受试者，这在组中无关紧要。结论：长期的糖尿病病程和升高的血糖状态可能会影响心血管健康、睡眠质量和生活质量，导致抑郁和疲劳。与 B 组相比，睡眠质量差，抑郁增加。 VO2max 与糖化血红蛋白呈显着负线性相关，糖化血红蛋白与糖尿病病程、睡眠质量差和抑郁呈显着正线性相关对于所有受试者，这在组中无关紧要。结论：长期的糖尿病病程和升高的血糖状态可能会影响心血管健康、睡眠质量和生活质量，导致抑郁和疲劳。和所有受试者的抑郁症，这在各组中无关紧要。结论：长期的糖尿病病程和升高的血糖状态可能会影响心血管健康、睡眠质量和生活质量，导致抑郁和疲劳。和所有受试者的抑郁症，这在各组中无关紧要。结论：长期的糖尿病病程和升高的血糖状态可能会影响心血管健康、睡眠质量和生活质量，导致抑郁和疲劳。